Elsevier

Journal of Affective Disorders

Volume 203, October 2016, Pages 121-129
Journal of Affective Disorders

Research Paper
Antenatal depression and adversity in urban South Africa

https://doi.org/10.1016/j.jad.2016.05.052Get rights and content

Highlights

  • The prevalence of antenatal depression amongst women living in adversity is high.

  • Women in such settings face multiple psychosocial and socioeconomic risk factors.

  • Food insecure women are at great risk for antenatal depression.

  • Interventions for women with low resources may be integrated into antenatal care.

Abstract

Background

In low and middle-income countries (LMIC), common mental disorders affecting pregnant women receive low priority, despite their disabling effect on maternal functioning and negative impact on child health and development. We investigated the prevalence of risk factors for antenatal depression among women living in adversity in a low-resource, urban setting in Cape Town, South Africa.

Methods

The MINI Neuropsychiatric Interview (MINI Plus) was used to measure the diagnostic prevalence of depression amongst women attending their first antenatal visit at a primary-level, community-based clinic. Demographic data were collected followed by administration of questionnaires to measure psychosocial risk. Analysis examined the association between diagnosis of depression and psychosocial risk variables, and logistic regression was used to investigate predictors for major depressive episode (MDE).

Results

Among 376 women participating, the mean age was 26 years. The MINI-defined prevalence of MDE was 22%, with 50% of depressed women also expressing suicidality. MDE diagnosis was significantly associated with multiple socioeconomic and psychosocial risk factors, including a history of depression or anxiety, food insecurity, experience of threatening life events and perceived support from family.

Limitations

The use of self-report measures may have led to recall bias. Retrospective collection of clinical data limited our ability to examine some known risk factors for mental distress.

Conclusion

These findings confirm the high prevalence of MDE among pregnant women in LMIC settings. Rates of depression may be increased in settings where women are exposed to multiple risks. These risk factors should be considered when planning maternal mental health interventions.

Section snippets

Background

Depressive disorders account for almost half of the burden of disease presented by mental disorders, followed by anxiety disorders, and drug and alcohol use disorders (WHO Department of Health Statistics and Informatics, 2008). Globally, the lifetime prevalence of major depressive disorder is estimated to be between 10% and 15% (Lépine and Briley, 2011) and in South Africa, it is estimated that 9.8% adults will experience a major depressive episode (MDE) at least once during their lifetime (

Setting

This cross-sectional study was undertaken at the Hanover Park Midwife Obstetric Unit (MOU), which provides primary level maternity services in an urban area of Cape Town, South Africa. Hanover Park has a population of about 35,000 people (Statistics South Africa, 2013), and is a community characterized by high levels of poverty and community-based gang violence. Hanover Park is regarded as one of the most violent parts of Cape Town with high rates of alcohol and substance abuse, physical and

Training

A research assistant and a mental health officer were appointed to conduct the study.5 A clinical psychologist, with research experience, trained and supervised both these staff. The research assistant was trained to recruit women, administer the demographics questionnaire and manage the study database. The

Description of the sample

A total of 376 women were recruited and completed the screening process (Table 1). Most women were in their mid-twenties, and in the second trimester of their second pregnancy. Although 90% of women were in an intimate relationship, only 56% were cohabiting with their partner. The average highest level of education achieved was Grade 10. Only 27% of women were employed on a full time basis, 18% had informal, contract or part time employment and 55% were unemployed. Only 5% were earning over

Discussion

This study used a clinical diagnostic tool to determine the prevalence of antenatal MDE in a low resource urban area. The prevalence of MDE in this sample is 22%, approximately double that of HIC settings but lower than some of the highest rates found in LMIC (Fisher et al., 2012). The wide range of prevalence rates reported in LMIC settings has been attributed to the limited local evidence available compared to HIC settings. According to Fisher et al. (2012), only 8% of LMIC have reliable

Conclusion

The high prevalence of depression amongst pregnant women in this study was significantly associated with multiple risk factors. Many of these have been cited in previous studies, but some were novel for the setting. The experience of multiple risk factors may elicit a significant stress response in the form of MDE, which has consequences for maternal and child health and well-being (Morgan et al., 2012). An integrated approach is recommended to provide mental health care as part of antenatal

Contributers

Thandi van Heyningen, Simone Honikman and Sally Field designed the study and wrote the protocol. Thandi van Heyningen supervised the study, the data collection, and managed the literature searches. Thandi van Heyningen, Landon Myer and Michael Onah undertook the statistical analyses. Thandi van Heyningen wrote the first draft of the manuscript. All authors contributed to and have approved the final manuscript.

Role of the funding source

This research study was funded by the Medical Research Council of South Africa and Cordaid. The preparation of the article was funded by the National Research Foundation of South Africa and the Harry Crossley Foundation, South Africa. None of the funding sources were involved in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.

Conflict of interest

The authors declare no conflict of interest.

Acknowledgments

The authors would like to acknowledge Bronwyn Evans, Liezl Hermanus and Sheily Ndwayana for their assistance with data collection, as well as the staff and patients of Hanover Park MOU.

References (90)

  • L. Myer et al.

    Social determinants of psychological distress in a nationally-representative sample of South African adults *

    Soc. Sci. Med.

    (2008)
  • V. Patel et al.

    Treatment and prevention of mental disorders in low-income and middle-income countries

    Lancet

    (2007)
  • R.M. Pearson et al.

    Disruption to the development of maternal responsiveness? The impact of prenatal depression on mother-infant interactions

    Infant Behav. Dev.

    (2012)
  • A. Rahman et al.

    Outcome of prenatal depression and risk factors associated with persistence in the first postnatal year: prospective study from Rawalpindi, Pakistan

    J. Affect. Disord.

    (2007)
  • P.G. Ramchandani et al.

    Predictors of postnatal depression in an urban South African cohort

    J. Affect. Disord.

    (2009)
  • E. Robertson et al.

    Antenatal risk factors for postpartum depression: a synthesis of recent literature

    Gen. Hosp. Psychiatry

    (2004)
  • T. Rochat et al.

    The prevalence and clinical presentation of antenatal depression in rural South Africa

    J. Affect. Disord.

    (2011)
  • S.M. Woods et al.

    Psychosocial stress during pregnancy

    Am. J. Obstet. Gynecol.

    (2010)
  • A.O. Adewuya et al.

    Prevalence of postnatal depression in Western Nigerian women: a controlled study

    Int. J. Psychiatry Clin. Pract.

    (2005)
  • M. Austin et al.

    The Antenatal Risk Questionnaire (ANRQ): acceptability and use for psychosocial risk assessment in the maternity setting

    Women Birth

    (2011)
  • C. Beck

    Predictors of postpartum depression: an update

    Nurs. Res.

    (2001)
  • A. Benjamin

    Community Counsellors' Experiences of Trauma and Resilience in a Low-Income Community

    (2014)
  • S.J. Blumberg et al.

    The effectiveness of a short form of the household food security scale

    Am. J. Public Health

    (1999)
  • K. Brittain et al.

    Risk factors for antenatal depression and associations with infant birth outcomes: results from a South African birth cohort study

    Paediatr. Perinat. Epidemiol.

    (2015)
  • T.S. Brugha et al.

    The list of threatening experiences: the reliability and validity of a brief life events questionnaire

    Acta Psychiatr. Scand.

    (1990)
  • A.E. Buist et al.

    To screen or not to screen—that is the question in perinatal depression

    Med. J. Aust.

    (2002)
  • R. Bunevicius et al.

    Psychosocial risk factors for depression during pregnancy

    Acta Obstet. Gynecol. Scand.

    (2009)
  • Chen, X., Ender, P., Mitchell, M., Wells, C., 2003. Regression with STATA. Los Angeles UCLA Acad. Technol....
  • P.Y. Collins et al.

    Grand challenges in global mental health

    Nature

    (2011)
  • J. Condon

    Women's mental health: a ‘wish-list’ for the DSM V

    Arch. Womens Ment. Health

    (2010)
  • P.J. Cooper et al.

    Postnatal depression

    Br. Med. J.

    (1998)
  • L.J. Cronbach

    Coefficient alpha and the internal structure of tests

    Psychometrika

    (1951)
  • Day, C., Gray, A., 2013. Health and Related Indicators, South African Health...
  • A. Deaton

    The Analysis of Household Surveys: A Microeconometric Approach to Development Policy

    (1997)
  • K.M. Devries et al.

    Intimate partner violence and incident depressive symptoms and suicide attempts : a systematic review of longitudinal studies

    PLoS Med.

    (2013)
  • S. Dewing et al.

    Food insecurity and its association with co-occurring postnatal depression, hazardous drinking, and suicidality among women in peri-urban South Africa

    J. Affect. Disord.

    (2013)
  • R.B. Dudas et al.

    Obstetric and psychosocial risk factors for depressive symptoms during pregnancy

    Psychiatry Res.

    (2012)
  • C. Dunkel Schetter et al.

    Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice

    Curr. Opin. Psychiatry

    (2012)
  • Dunkle, K., Jewkes, R., Brown, H., Mcintyre, J., Gray, G., Harlow, S., 2003. Gender-based violence and HIV infection...
  • K.L. Dunkle et al.

    Prevalence and patterns of gender-based violence and revictimization among women attending antenatal clinics in Soweto, South Africa

    Am. J. Epidemiol.

    (2004)
  • A. Faisal-Cury et al.

    Common mental disorders during pregnancy: prevalence and associated factors among low-income women in São Paulo, Brazil: depression and anxiety during pregnancy

    Arch. Womens Ment. Health

    (2009)
  • D. Filmer et al.

    Estimating wealth effects without expenditure data-or tears: an application to educational enrollments in states of India

    Demography

    (2001)
  • J. Fisher et al.

    Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review

    Bull. World Health Organ.

    (2012)
  • J. Garcia et al.

    Persistent household food insecurity, HIV, and maternal stress in Peri-Urban Ghana

    BMC Public Health

    (2013)
  • A. Garg et al.

    Influence of maternal depression on household food insecurity for low-income families

    Acad. Pediatr.

    (2014)
  • Cited by (0)

    View full text