Journal of Affective Disorders
Volume 121, Issue 1 , Pages 143-146 , February 2010

Onset-age of bipolar disorders at six international sites

  • R.J. Baldessarini

      Affiliations

    • Department of Psychiatry & Neuroscience Program, Harvard Medical School, USA
    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Corresponding Author InformationCorresponding author. Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478-9106, USA.
    • ,
  • L. Bolzani

      Affiliations

    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Department of Psychiatry, Viarnetto Psychiatric Clinic, Lugano, Switzerland
    • Department of Psychiatry, University of Cagliari; Lucio Bini Mood Disorder Center, Cagliari, Sardinia, Italy
    • ,
  • N. Cruz

      Affiliations

    • Department of Psychiatry & Neuroscience Program, Harvard Medical School, USA
    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Spain
    • ,
  • P.B. Jones

      Affiliations

    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Spain
    • ,
  • M. Lai

      Affiliations

    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Department of Psychiatry, Viarnetto Psychiatric Clinic, Lugano, Switzerland
    • Department of Psychiatry, University of Cagliari; Lucio Bini Mood Disorder Center, Cagliari, Sardinia, Italy
    • ,
  • B. Lepri

      Affiliations

    • Department of Psychiatry, Viarnetto Psychiatric Clinic, Lugano, Switzerland
    • Department of Psychiatry, University of Cagliari; Lucio Bini Mood Disorder Center, Cagliari, Sardinia, Italy
    • ,
  • J. Perez

      Affiliations

    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • CAMEO Early Intervention Services, Department of Psychiatry, University of Cambridge, UK
    • ,
  • P. Salvatore

      Affiliations

    • Department of Psychiatry & Neuroscience Program, Harvard Medical School, USA
    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Department of Neuroscience, Section of Psychiatry, University of Parma, Italy
    • ,
  • M. Tohen

      Affiliations

    • Department of Psychiatry & Neuroscience Program, Harvard Medical School, USA
    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Department of Psychiatry, University of Texas, San Antonio, TX, United States
    • ,
  • L. Tondo

      Affiliations

    • Department of Psychiatry & Neuroscience Program, Harvard Medical School, USA
    • Department of Psychiatry, Viarnetto Psychiatric Clinic, Lugano, Switzerland
    • Department of Psychiatry, University of Cagliari; Lucio Bini Mood Disorder Center, Cagliari, Sardinia, Italy
    • ,
  • E. Vieta

      Affiliations

    • International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    • Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Spain

Received 6 February 2009 ,Revised 27 May 2009 ,Accepted 28 May 2009.

References 

  1. Benazzi F. Classifying mood disorders by age-at-onset instead of polarity. Prog. Neuro-psychopharmacol. Biol. Psychiatry. 2009;33:86–93
  2. Chengappa KN, Kupfer DJ, Frank E, Houck PR, Grochocinski VJ, Cluss PA, et al. Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry. Am. J. Psychiatry. 2003;160:1636–1642
  3. Colom F, Vieta E. The road to DSM-V: bipolar disorder episode and course specifiers. Psychopathology. 2009;42:209–218
  4. Engström C, Brändström S, Sigvardsson S, Cloninger R, Nylander PO. Bipolar disorder: personality and age of onset. Bipolar Disord. 2003;5:340–348
  5. Goodwin FK, Jamison KR. Manic-Depressive Illness. Second edition. New York, NY: Oxford University Press; 2007;
  6. Joyce PR. Age of onset in bipolar affective disorder and misdiagnosis as schizophrenia. Psychol. Med. 1984;14:145–149
  7. Kennedy N, Everitt B, Boydell J, Van Os J, Jones PB, Murray RM. Incidence and distribution of first-episode mania by age: results from a 35-year study. Psychol. Med. 2005;2005:855–863
  8. Kupfer DJ, Frank E, Grochocinski VJ, Cluss PA, Houck PR, Stapf DA. Demographic and clinical characteristics of individuals in a bipolar disorder case registry. J. Clin. Psychiatry. 2002;63:120–125
  9. Leboyer M, Henry C, Paillere-Martinot ML, Bellivier F. Age at onset in bipolar affective disorders: review. Bipolar Disord. 2005;7:111–188
  10. McElroy SL, Strakowski SM, West SA, Keck PE, McConville BJ. Phenomenology of adolescent and adult mania in hospitalized patients with bipolar disorder. Am. J. Psychiatry. 1997;154:44–49
  11. Mick E, Biederman J, Faraone SV, Murray K, Wozniak J. Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset. J. Child Adolesc. Psychopharmacol. 2003;13:453–462
  12. Post RM, Luckenbaugh DA, Leverich GS, Altshuler LL, Frye MA, Suppes T, et al. Incidence of childhood-onset bipolar illness in the USA and Europe. Br. J. Psychiatry. 2008;192:150–151
  13. Salvatore P, Khalsa HMK, Hennen J, Tohen M, Yurgelun-Todd D, Casolari F, et al. Psychopathology factors in first-episode affective and nonaffective psychotic disorders. J. Psychiatr. Res. 2007;41:724–736
  14. Salvatore P, Tohen M, Khalsa HMK, Baethge C, Tondo L, Baldessarini RJ. Longitudinal research on bipolar disorders. Epidemiol. Psychiatr. Soc. 2007;16:109–117(Rome)
  15. Salvatore P, Baldessarini RJ, Tohen M, Khalsa HMK, Perez Sanchez-Toledo J, Zarate CA, et al. McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients. J. Clin. Psychiatry. 2009;70:458–466
  16. Strober M. Relevance of early age-of-onset in genetic studies of bipolar affective disorder. J. Am. Acad. Child Adolesc. Psych. 1992;31:606–610
  17. Yildiz A, Sachs GS. Age onset of psychotic versus non-psychotic bipolar illness in men and in women. J. Affect. Disord. 2003;74:197–201

☆ Disclosures: Dr. Baldessarini has recently been a consultant or investigator-initiated research collaborator with: AstraZeneca, Auritec, Biotrofix, Janssen, JDS-Noven, Lilly, Luitpold, NeuroHealing, Novartis, Pfizer, and SK-BioPharmaceutical Corporation; he is not a member of pharmaceutical speakers' bureaus, nor does he or any family member hold equity positions in biomedical or pharmaceutical corporations. Dr. Perez is a former employee of Eli Lilly Corporation (to 2004). Dr. Tohen was an employee of Eli Lilly & Co (to 2008), and is a consultant or has received speaker's honoraria from Astra-Zeneca, BristolMyers-Squibb, Eli Lilly, Glaxo-SmithKline, Johnson & Johnson and Wyeth Corporations; his spouse is an Eli Lilly employee and stockholder. Dr. Vieta has served as a consultant or speaker for Astra-Zeneca, BristolMyers-Squibb, Eli Lilly, Forest Research Institute, Glaxo-Smith-Kline, Janssen-Cilag, Jazz, Lundbeck, Merck, Novartis, Organon, Otsuka, Pfizer, Sanofi-Aventis, Servier, Shering-Plough, United Biosource, and Wyeth Corporations. Other authors have no relevant disclosures of potential conflicts of interest.

PII: S0165-0327(09)00253-5

doi: 10.1016/j.jad.2009.05.030

Journal of Affective Disorders
Volume 121, Issue 1 , Pages 143-146 , February 2010

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