Journal of Affective Disorders
Volume 122, Issue 1 , Pages 10-13, April 2010

Women's Reproductive Related Disorders (RRDs)

  • Uriel Halbreich

      Affiliations

    • Corresponding Author InformationTel.: +1 716 829 3808, +1 716 316 4440; fax: +1 716 829 3812.

Biobehavior Program, SUNY-AB, School of Medicine and Biomedical Sciences, Hayes C, Suite 1, 3435 Main Street, Building 5, Buffalo, NY 14214-3016, United States

Received 3 January 2009; accepted 12 May 2009.

Abstract 

Background

In some but not all women, periods of hormonal change may be associated with diversified physical, mental and cognitive symptoms that may be severe enough to warrant treatment. These reproductive-life periods include pregnancy, post-partum, the premenstrual and perimenopausal periods.

Conclusions

Disorders during these periods are quite prevalent and may be grouped together as Reproductive Related Disorders (RRDs). They are characterized by their timing, epidemiologic associations and shared vulnerabilities, but not necessarily by their descriptive phenomenology that often times is diversified among women but consistent within each individual woman.

The pathophysiology of RRDs is suggested to be maladaptation of vulnerable women to normal hormonal changes. As such, RRDs provide for an interdisciplinary diagnostic model of mostly-affective disorders that differ from the current descriptive-based entities.

Clinical relevance

Treatment options may be aimed at the trigger—the hormonal changes or instability; or may be symptomatic—in cases of depression or anxiety they are mostly SSRIs.

Keywords: Women, Reproductive age, Affective disorders, Hormones, Pathophysiology

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PII: S0165-0327(09)00217-1

doi:10.1016/j.jad.2009.05.018

Journal of Affective Disorders
Volume 122, Issue 1 , Pages 10-13, April 2010