Journal of Affective Disorders
Volume 119, Issue 1 , Pages 107-115 , December 2009

Interaction between genetic polymorphisms and stressful life events in first episode depression

  • Jens Drachmann Bukh

      Affiliations

    • Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark. Tel.: +45 3545 6230; fax: +45 3545 6218.
    • ,
  • Camilla Bock

      Affiliations

    • Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Maj Vinberg

      Affiliations

    • Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Thomas Werge

      Affiliations

    • Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark
    • ,
  • Ulrik Gether

      Affiliations

    • Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark
    • ,
  • Lars Vedel Kessing

      Affiliations

    • Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark

Received 6 January 2009 ,Revised 26 February 2009 ,Accepted 26 February 2009.

References 

  1. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry. 1961;4:561–571
  2. Bondy B, Kuznik J, Baghai T, Schule C, Zwanzger P, Minov C, et al. Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide. Am. J. Med. Genet. 2000;96:831–835
  3. Brummett BH, Boyle SH, Siegler IC, Kuhn CM, shley-Koch A, Jonassaint CR, et al. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav. Genet. 2008;38:34–43
  4. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389
  5. Cervilla JA, Molina E, Rivera M, Torres-Gonzalez F, Bellon JA, Moreno B, et al. The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort. Mol. Psychiatry. 2007;12:748–755
  6. Chipman P, Jorm AF, Prior M, Sanson A, Smart D, Tan X, et al. No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007;144B:561–565
  7. Chorbov VM, Lobos EA, Todorov AA, Heath AC, Botteron KN, Todd RD. Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007;144:830–833
  8. Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, et al. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biol. Psychiatry. 2007;61:223–230
  9. Covault J, Tennen H, Armeli S, Conner TS, Herman AI, Cillessen AH, et al. Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol. Psychiatry. 2007;61:609–616
  10. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112:257–269
  11. Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, et al. Gene–environment interaction analysis of serotonin system markers with adolescent depression. Mol. Psychiatry. 2004;9:908–915
  12. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS. In: The Structured Clinical Interview for DSM — IV Axis II Personality Disorders (SCID — II). Washington: American Psychiatric Press; 1997;
  13. Gillespie NA, Whitfield JB, Williams B, Heath AC, Martin NG. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol. Med. 2005;35:101–111
  14. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry. 1960;23:56–62
  15. Jacobs N, Kenis G, Peeters F, Derom C, Vlietinck R, Van OJ. Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch. Gen. Psychiatry. 2006;63:989–996
  16. Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol. Psychiatry. 2006;59:673–680
  17. Kendler KS, Baker JH. Genetic influences on measures of the environment: a systematic review. Psychol. Med. 2007;37:615–626
  18. Kendler KS, Karkowski LM, Prescott CA. Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. J. Nerv. Ment. Dis. 1998;186:661–669
  19. Kendler KS, Thornton LM, Gardner CO. Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am. J. Psychiatry. 2000;157:1243–1251
  20. Kendler KS, Thornton LM, Gardner CO. Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. Am. J. Psychiatry. 2001;158:582–586
  21. Kendler KS, Gardner CO, Prescott CA. Personality and the experience of environmental adversity. Psychol. Med. 2003;33:1193–1202
  22. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch. Gen. Psychiatry. 2005;62:529–535
  23. Kendler KS, Gatz M, Gardner CO, Pedersen NL. Personality and major depression: a Swedish longitudinal, population-based twin study. Arch. Gen. Psychiatry. 2006;63:1113–1120
  24. Khoury MJ, Flanders WD. Nontraditional epidemiologic approaches in the analysis of gene–environment interaction: case–control studies with no controls!. Am. J. Epidemiol. 1996;144:207–213
  25. Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, et al. The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. Am. J. Psychiatry. 2007;164:1693–1699
  26. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Kim YH, et al. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol. Psychiatry. 2007;62:423–428
  27. Lazary J, Lazary A, Gonda X, Benko A, Molnar E, Juhasz G, et al. New Evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype. Biol. Psychiatry. 2008;
  28. Lenze EJ, Munin MC, Ferrell RE, Pollock BG, Skidmore E, Lotrich F, et al. Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am. J. Geriatr. Psychiatry. 2005;13:428–432
  29. Loranger AW, Lenzenweger MF, Gartner AF, Susman VL, Herzig J, Zammit GK, et al. Trait-state artifacts and the diagnosis of personality disorders. Arch. Gen. Psychiatry. 1991;48:720–728
  30. Mandelli L, Serretti A, Marino E, Pirovano A, Calati R, Colombo C. Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int. J. Neuropsychopharmacol. 2007;10:437–447
  31. Munk-Jorgensen P, Mortensen PB. The Danish psychiatric central register. Dan. Med. Bull. 1997;44:82–84
  32. Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol. Psychiatry. 2000;5:32–38
  33. Nakatani D, Sato H, Sakata Y, Shiotani I, Kinjo K, Mizuno H, et al. Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. Am. Heart J. 2005;150:652–658
  34. Paykel ES. The interview for recent life events. Psychol. Med. 1997;27:301–310
  35. Peselow ED, Sanfilipo MP, Fieve RR, Gulbenkian G. Personality traits during depression and after clinical recovery. Br. J. Psychiatry. 1994;164:349–354
  36. Post RM. Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am. J. Psychiatry. 1992;149:999–1010
  37. Power T, Stewart R, Ancelin ML, Jaussent I, Malafosse A, Ritchie K. 5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population. Neurobiol. Aging. 2008;
  38. Praschak-Rieder N, Kennedy J, Wilson AA, Hussey D, Boovariwala A, Willeit M, et al. Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study. Biol. Psychiatry. 2007;62:327–331
  39. Rasmussen HB, Werge TM. Novel procedure for genotyping of the human serotonin transporter gene-linked polymorphic region (5-HTTLPR) — a region with a high level of allele diversity. Psychiatr. Genet. 2007;17:287–291
  40. Scheid JM, Holzman CB, Jones N, Friderici KH, Nummy KA, Symonds LL, et al. Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype. Genes Brain Behav. 2007;6:453–464
  41. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004;127B:85–89
  42. Sjoberg RL, Nilsson KW, Nordquist N, Ohrvik J, Leppert J, Lindstrom L, et al. Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int. J. Neuropsychopharmacol. 2006;9:443–449
  43. Strobel A, Gutknecht L, Rothe C, Reif A, Mossner R, Zeng Y, et al. Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J. Neural Transm. 2003;110:1445–1453
  44. Surtees PG, Wainwright NW, Willis-Owen SA, Luben R, Day NE, Flint J. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol. Psychiatry. 2006;59:224–229
  45. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol. Psychiatry. 2008;13:131–146
  46. Van OJ, Park SB, Jones PB. Neuroticism, life events and mental health: evidence for person–environment correlation. Br. J. Psychiatry. 2001;(Suppl 40):s72–s77
  47. Wichers M, Kenis G, Jacobs N, Mengelers R, Derom C, Vlietinck R, et al. The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: an attempt at replication. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008;147B:120–123
  48. Wilhelm K, Mitchell PB, Niven H, Finch A, Wedgwood L, Scimone A, et al. Life events, first depression onset and the serotonin transporter gene. Br. J. Psychiatry. 2006;188:210–215
  49. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R, et al. SCAN. Schedules for clinical assessment in neuropsychiatry. Arch. Gen. Psychiatry. 1990;47:589–593
  50. World Health Organisation . In: The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organisation; 1992;
  51. Zalsman G, Huang YY, Oquendo MA, Burke AK, Hu XZ, Brent DA, et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am. J. Psychiatry. 2006;163:1588–1593

PII: S0165-0327(09)00096-2

doi: 10.1016/j.jad.2009.02.023

Journal of Affective Disorders
Volume 119, Issue 1 , Pages 107-115 , December 2009

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