Journal of Affective Disorders
Volume 117, Issue 3 , Pages 137-145 , October 2009

Transcranial direct current stimulation: A new tool for the treatment of depression?

  • Abraham P. Arul-Anandam

      Affiliations

    • School of Psychiatry, University of New South Wales, Sydney, Australia
  • ,
  • Colleen Loo

      Affiliations

    • School of Psychiatry, University of New South Wales, Sydney, Australia
    • Black Dog Institute, St George Hospital, Sydney, Australia
    • Corresponding Author InformationCorresponding author. Black Dog Institute, Prince of Wales Hospital, Barker St, Randwick, 2031, Australia. Tel.: +61 2 9382 3721; fax: +61 2 9382 8208.

Received 15 December 2008 ,Revised 16 January 2009 ,Accepted 16 January 2009.

References 

  1. Amodio P, Gatta A. Neurophysiological investigation of hepatic encephalopathy. Metab. Brain Dis. 2005;20:369–379
  2. Antal A, Nitsche MA, Paulus W. Transcranial direct current stimulation and the visual cortex. Brain Res. Bull. 2006;68:459–463
  3. Ardolino G, Bossi B, Barbieri S, Priori A. Non-synaptic mechanisms underlie the after effects of cathodal transcutaneous direct current stimulation of the human brain. J Physiol. 2005;568:653–663
  4. Arfai E, Theano G, Montagu JD, Robin AA. A controlled study of polarisation in depression. Br. J. Psychiatry. 1970;116:433–434
  5. Baker AB. Brain stem polarization in the treatment of depression. S. Afr. Med. J. 1970;44:473–475
  6. Baudewig J, Nitsche MA, Paulus W, Frahm J. Regional modulation of BOLD MRI responses to human sensorimotor activation by transcranial direct current stimulation. Magn. Reson. Med. 2001;45:196–201
  7. Bienenstock EL, Cooper LN, Munro PW. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J. Neurosci. 1982;2:32–48
  8. Bikson M, Inoue M, Akiyama H, Deans JK, Fox JE, Miyakawa H, et al. Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro. J. Physiol. 2004;557:175–190
  9. Bindman LJ, Lippold OCJ, Redfearn JWT. The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. J. Physiol. 1964;172:369–382
  10. Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone AP, et al. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int. J. Neuropsychopharmacol. 2008;11:249–254
  11. Carney MWP, Cashman MD, Sheffield BF. Polarization in depression. Br. J. Psychiatry. 1970;117:474–475
  12. Chesler M. Regulation and modulation of pH in the Brain. Physiol Rev. 2003;83:183–1221
  13. Chow CC, White JA. Spontaneous action potentials due to channel fluctuations. Biophys. J. 1996;71:3013–3021
  14. Cooke SF, Bliss TVP. Plasticity in the human central nervous system. Brain. 2006;129:1659–1673
  15. Costain R, Redfearn JWT, Lippold OCJ. A controlled trial of the therapeutic effects of polarization of the brain in depressive illness. Br. J. Psychiatry. 1964;110:786–799
  16. Debanne D, Daoudal G, Sourdet V, Russier M. Brain plasticity and ion channels. J. Physiol. Paris. 2003;97:403–414
  17. Fregnac Y, Smith D, Friedlander MJ. Postsynaptic membrane potentiation regulates synaptic potentiation and depression in visual cortical neurons. Soc. Neurosci. Abstr. 1990;16:798
  18. Fregni F, Boggio PS, Nitsche M, Marcolin MA, Rigonatti SP, Pascual-Leone A. Treatment of major depression with transcranial direct current stimulation. Bipolar. Disord. 2006;8:203–204
  19. Froc DJ, Chapman CA, Trepel C, Racine RJ. Long-term depression and depotentiation in the sensorimotor cortex of the freely moving rat. J. Neurosci. 2000;20:438–445
  20. Gandiga PC, Hummel FC, Cohen LG. Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin. Neurophysiol. 2006;117:845–850
  21. Gartside IB. Mechanisms of sustained increases of firing rate of neurones in the rat cerebral cortex after polarization: reverberating circuits or modification of synaptic conductance?. Nature. 1968;220:382–383
  22. Gartside IB. Mechanisms of sustained increases of firing rate of neurones in the rat cerebral cortex after polarization: role of protein synthesis. Nature. 1968;220:383–384
  23. Gershon AA, Dannon PN, Grunhaus L. Transcranial magnetic stimulation in the treatment of depression. Am. J. Psychiatry. 2003;160:835–845
  24. Greengard P, Jen J, Nairn AC, Stevens CF. Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science. 1991;253:1135–1138
  25. Hardingham NR, Bannister NJ, Read JCA, Fox KD, Hardingham GE, Jack JB. Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors. J. Neurosci. 2006;26:6337–6345
  26. Hattori Y, Moriwaki A, Hori Y. Biphasic effects of polarizing current on adenosine-sensitive generation of cyclic AMP in rat cerebral cortex. Neurosci. Lett. 1990;116:320–324
  27. Herjanic M, Moss-Herjanic B. Clinical report on a new therapeutic technique: polarization. Can. Psychiatr. Assoc. J. 1967;12:423–424
  28. Ishibashi H, Eto K, Kajiwara M, Noda M. Facilitation of spontaneous glutamate release by antidepressant drugs in rat locus coeruleus. Neurosci. Lett. 2005;374:152–256
  29. Islam N, Aftabuddin M, Moriwaki A, Hattori Y, Hori Y. Increase in the calcium level following anodal polarization in the rat brain. Brain Res. 1995;684:206–208
  30. Jaffe LF. Electrophoresis along cell membranes. Nature. 1977;265:600–602
  31. Lang N, Siebner HR, Ernst D, Nitsche MA, Paulus W, Lemon RN, et al. Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects. Biol. Psychiatry. 2004;56:634–639
  32. Lang N, Siebner HR, Ward NS, Lee L, Nitsche MA, Paulus W, et al. How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?. Eur. J. Neurosci. 2005;22:495–504
  33. Liebetanz D, Nitsche MA, Tergau F, Paulus W. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain. 2002;125:2238–2247
  34. Lippold OCJ, Redfearn JWT. Mental changes resulting from the passage of small direct currents through the human brain. Br. J. Psychiatry. 1964;110:768–772
  35. Logothetis NK. What we can do and what we cannot do with fMRI. Nature. 2008;453:869–878
  36. Malenka RC, Bear MF. LTP and LTD: an embarrassment of riches. Neuron. 2004;44:5–21
  37. Michael N, Gösling M, Reutemann M, Kersting A, Heindel W, Arolt V, et al. Metabolic changes after repetitive transcranial magnetic stimulation (rTMS) of the left prefrontal cortex: a sham-controlled proton magnetic resonance spectroscopy (1H MRS) study of healthy brain. Eur. J. Neurosci. 2003;17:2462–2468
  38. Moriwaki A. Polarizing currents increase noradrenaline-elicited accumulation of cyclic AMP in rat cerebral cortex. Brain Res. 1991;544:248–252
  39. Nias DKB, Shapiro MB. The effects of small electrical currents upon depressive symptoms. Br. J. Psychiatry. 1974;125:414–415
  40. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J. Physiol. 2000;527:633–639
  41. Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology. 2001;57:1899–1901
  42. Nitsche MA, Fricke K, Henschke A, Schlitterlau D, Liebetanz N, Lang S, et al. Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J. Physiol. 2003;553:293–301
  43. Nitsche MA, Liebetanz D, Lang N, Antal A, Frithjof T, Paulus W. Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clin. Neurophysiol. 2003;114:2220–2222
  44. Nitsche MA, Jaussi W, Liebetanz D, Lang N, Tergau F, Paulus W. Consolidation of human motor cortical neuroplasticity by d-cycloserine. Neuropsychopharmacology. 2004;29:1573–1578
  45. Nitsche MA, Seeber A, Frommann K, Klein CC, Rochford C, Nitsche MS, et al. Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex. J. Physiol. 2005;568:291–303
  46. Nitsche MA, Lampe C, Antal A, Liebetanz D, Lang N, Tergau F, et al. Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex. Eur. J. Neurosci. 2006;23:1651–1657
  47. Palm U, Keeser D, Schiller C, Fintescu Z, Reisinger E, Padberg F, et al. Skin lesions after treatment with transcranial direct current stimulation (tDCS). Brain Stim. 2008;1:386–387
  48. Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology. 2007;33:88–109
  49. Priori A. Brain polarization in humans: a reappraisal of an old tool for prolonged non-invasive modulation of brain excitability. Clin. Neurophysiol. 2003;114:589–595
  50. Priori A, Berardelli A, Rona S, Accornero N, Manfredi M. Polarization of the human motor cortex through the scalp. Neuroreport. 1998;9:2257–2260
  51. Purpura DP, McMurtry JG. Intracellular activities and evoked potential changes during polarization of the motor cortex. J. Neurophysiol. 1965;28:166–185
  52. Ramsay JC, Schlagenhauf G. Treatment of depression with low voltage direct current. South Med. J. 1966;59:932–934
  53. Rango M, Cogiamanian F, Marceglia S, Barberis B, Arighi A, Biondetti P, et al. Myoinositol content in the human brain is modified by transcranial direct current stimulation in a matter of minutes: A H-MRS study. Magn. Reson. Imaging. 2008;60:782–789
  54. Redfearn JWT, Lippold OCJ, Costain R. A preliminary account of the clinical effects of polarizing the brain in certain psychiatric disorders. Br. J. Psychiatry. 1964;110:773–785
  55. Rigonatti SP, Boggio PS, Myczkowski ML, Otta E, Fiquer JT, Ribeiro RB, et al. Transcranial direct stimulation and fluoxetine for the treatment of depression. Eur. Psychiatry. 2008;23:74–76
  56. Rosenkranz K, Nitsche MA, Tergau F, Paulus W. Diminution of training-induced transient motor cortex plasticity by weak transcranial direct current stimulation in the human. Neurosci. Lett. 2000;296:61–63
  57. Ruohonen J. Background physics for magnetic stimulation. Suppl. Clin. Neurophysiol. 2003;56:3–12
  58. Siebner HR, Lang N, Rizzo V, Nitsche MA, Paulus W, Lemon RN, et al. Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex. J. Neurosci. 2004;24:3379–3385
  59. Somjen GG, Tombaugh GC. pH modulation of neuronal excitability and central nervous system functions. In:  Kaila K,  Ransom BR editor. pH and Brain Function. New York: Wiley-Liss; 1998;p. 373–395
  60. Stollberg J, Fraser SE. Acetylcholine receptors and concanavalin A-binding sites on cultured xenopus muscle cells: electrophoresis, diffusion, and aggregation. J. Cell Biol. 1988;107:1397–1408
  61. Tehovnik EJ. Electrical stimulation of neural tissue to evoke behavioral responses. J. Neurosci. Methods. 1996;65:1–17
  62. Terzuolo CA, Bullock TH. Measurement of imposed voltage gradient adequate to modulate neuronal firing. Proc. Natl. Acad. Sci. U. S. A. 1956;42:687–694
  63. Tsodyks M, Kenet T, Grinvald A, Arieli A. Linking spontaneous activity of single cortical neurons and the underlying functional architecture. Science. 1999;286:1943–1946
  64. Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial direct current stimulation: a computer-based human model study. Neuroimage. 2007;35:1113–1124
  65. Weiner RD. The psychiatric use of electrically induced seizures. Am. J. Psychiatry. 1979;136:1507–1517

PII: S0165-0327(09)00035-4

doi: 10.1016/j.jad.2009.01.016

Journal of Affective Disorders
Volume 117, Issue 3 , Pages 137-145 , October 2009