Journal of Affective Disorders
Volume 117, Issue 3 , Pages 146-150, October 2009

Efficacy of high frequency (rapid) suprathreshold repetitive transcranial magnetic stimulation of right prefrontal cortex in bipolar mania: A randomized sham controlled study

  • Samir Kumar Praharaj

      Affiliations

    • Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India, 834006
    • Corresponding Author InformationCorresponding author. Tel.: +91 651 2231689; fax: +91 9431345765.
    • ,
  • Daya Ram

      Affiliations

    • Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India, 834006
    • ,
  • Manu Arora

      Affiliations

    • Government Medical College Jammu, Jammu & Kashmir, India

Received 26 September 2008; received in revised form 30 December 2008; accepted 31 December 2008.

Abstract 

Objective

To examine the efficacy of adjunctive right prefrontal high-frequency suprathreshold rTMS treatment in bipolar affective disorder, mania patients as compared to sham stimulation.

Method

41 right handed bipolar mania patients were randomized to receive daily sessions of active or sham rTMS (20 Hz, 110% of MT, 20 trains, 10 s intertrain interval) over the right dorsolateral prefrontal cortex for 10 days. Mania was rated using Young Mania Rating Scale (YMRS) and Clinical Global Impression (CGI) at baseline, and after 5th and 10th rTMS.

Result

For YMRS scores, repeated measures ANOVA showed a significant effect of treatment over time as shown by interaction effect (F=12.95, df=1.51/58.94, p<0.001, Greenhouse-Geisser corrected). For CGI-S, repeated measures ANOVA showed a significant interaction effect of treatment over time (F=5.34, df=1.36/53.01, p=0.016, Greenhouse-Geisser corrected).

Conclusion

High-frequency supra-threshold right prefrontal rTMS in bipolar, mania patients was well tolerated and found to be effective as add-on to standard pharmacotherapy.

Keywords: Bipolar affective disorder, Mania, rTMS

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PII: S0165-0327(09)00004-4

doi:10.1016/j.jad.2008.12.020

Journal of Affective Disorders
Volume 117, Issue 3 , Pages 146-150, October 2009

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