Journal of Affective Disorders
Volume 97, Issue 1 , Pages 51-59 , January 2007

Clinical characteristics of bipolar disorder in very young children

  • Arman Danielyan

      Affiliations

    • Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, D-3014, Cincinnati, OH 45229, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 513 636 1838; fax: +1 513 636 4283.
    • ,
  • Sanjeev Pathak

      Affiliations

    • Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, D-3014, Cincinnati, OH 45229, United States
    • Department of Psychiatry, University of Cincinnati Medical Center, United States
    • ,
  • Robert A. Kowatch

      Affiliations

    • Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, D-3014, Cincinnati, OH 45229, United States
    • Department of Psychiatry, University of Cincinnati Medical Center, United States
    • ,
  • Sarah P. Arszman

      Affiliations

    • Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, D-3014, Cincinnati, OH 45229, United States
    • ,
  • Erin S. Johns

      Affiliations

    • Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, D-3014, Cincinnati, OH 45229, United States

Received 10 February 2006 ,Revised 17 May 2006 ,Accepted 25 May 2006.

References 

  1. Akiskal HS, Downs J, Jordan P, Watson S, Daugherty D, Pruitt DB. Affective disorders in referred children and younger siblings of manic-depressives. Mode of onset and prospective course. Archives of General Psychiatry. 1985;42:996–1003
  2. Biederman J. Resolved: mania is mistaken for ADHD in prepubertal children. Journal of the American Academy of Child and Adolescent Psychiatry. 1998;37:1096–1098
  3. Biederman J, Klein RG, Pine DS, Klein DF. Resolved: mania is mistaken for ADHD in prepubertal children. Journal of the American Academy of Child and Adolescent Psychiatry. 1998;37:1091–1096
  4. Biederman J, Mick E, Bostic JQ, Prince J, Daly J, Wilens TE, et al. The naturalistic course of pharmacologic treatment of children with manic-like symptoms: a systematic chart review. Journal of Clinical Psychiatry. 1998;59:628–637
  5. Biederman J, Mick E, Faraone SV, Van Patten S, Burback M, Wozniak J. A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder. Journal of Affective Disorders. 2004;82:S17–S23
  6. Biederman J, Mick E, Hammerness P, Harpold T, Aleardi M, Dougherty M, et al. Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children. Biological Psychiatry. 2005;58:589–594
  7. Carlson GA. Classification issues of bipolar disorders in childhood. Psychiatric Developments. 1984;2:273–285
  8. Carlson GA. Identifying prepubertal mania. Journal of the American Academy of Child and Adolescent Psychiatry. 1995;34:750–753
  9. Carlson GA, Bromet EJ, Sievers S. Phenomenology and outcome of subjects with early- and adult-onset psychotic mania. American Journal of Psychiatry. 2000;157:213–219
  10. Carlson GA, Bromet EJ, Driessens C, Mojtabai R, Schwartz JE. Age at onset, childhood psychopathology, and 2-year outcome in psychotic bipolar disorder. American Journal of Psychiatry. 2002;159:307–309
  11. Craney JL, Geller B. A prepubertal and early adolescent bipolar disorder-I phenotype: review of phenomenology and longitudinal course. Bipolar Disorders. 2003;5:243–256
  12. DelBello MP, Soutullo CA, Hendricks W, Niemeier RT, McElroy SL, Strakowski SM. Prior stimulant treatment in adolescents with bipolar disorder: association with age at onset. Bipolar Disorders. 2001;3:53–57
  13. Dilsaver SC, Akiskal HS. Preschool-onset mania: incidence, phenomenology and family history. Journal of Affective Disorders. 2004;82:S35–S43
  14. Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB. Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disorders. 2004;6(4 (August)):305–313
  15. Findling RL, Gracious BL, McNamara NK, Youngstrom EA, Demeter CA, Branicky LA, et al. Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disorders. 2001;3:202–210
  16. Geller B, Luby J. Child and adolescent bipolar disorder: a review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:1168–1176
  17. Geller B, Williams M, Zimerman B, Frazier J, Beringer L, Warner KL. Prepubertal an early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. Journal of Affective Disorders. 1998;51:81–91
  18. Geller B, Bolhofner K, Craney JL, Williams M, DelBello MP, Gundersen K. Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype. Journal of the American Academy of Child and Adolescent Psychiatry. 2000;39:1543–1548
  19. Geller B, Zimerman B, Williams M, Bolhofner K, Craney JL, Delbello MP, et al. Diagnostic characteristics of 93 cases of a prepubertal and early adolescent bipolar disorder phenotype by gender, puberty and comorbid attention deficit hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology. 2000;10:157–164
  20. Geller B, Zimerman B, Williams M, Bolhofner K, Craney JL, Delbello MP, et al. Six-month stability and outcome of a prepubertal and early adolescent bipolar disorder phenotype. Journal of Child and Adolescent Psychopharmacology. 2000;10:165–173
  21. Geller B, Craney JL, Bolhofner K, Delbello MP, Williams M, Zimerman B. One-year recovery and relapse rates of children with a prepubertal and early adolescent bipolar disorder phenotype. American Journal of Psychiatry. 2001;158:303–305
  22. Geller B, Zimerman B, Williams M, Delbello MP, Bolhofner K, Craney JL, et al. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. Journal of Child and Adolescent Psychopharmacology. 2002;12:11–25
  23. Geller B, Tillman R, Craney JL, Bolhofner K. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Archives of General Psychiatry. 2004;61:459–467
  24. Greenhill LL. The use of psychotropic medication in preschoolers: indications, safety, and efficacy. Canadian Journal of Psychiatry-Revue Canadienne de Psychiatrie. 1998;43:576–581
  25. Jairam R, Srinath S, Girimaji SC, Seshadri SP. A prospective 4–5 year follow-up of juvenile onset bipolar disorder. Bipolar Disorders. 2004;6:386–394
  26. Kowatch RA. Mania in young children [comment]. Journal of the American Academy of Child and Adolescent Psychiatry. 1998;37:1003–1005
  27. Kowatch RA, Sethuraman G, Hume JH, Kromelis M, Weinberg WA. Combination pharmacotherapy in children and adolescents with bipolar disorder. Biological Psychiatry. 2003;53:978–984
  28. Kowatch RA, Fristad M, Birmaher B, Wagner KD, Findling RL, Hellander M, et al. Treatment guidelines for children and adolescents with bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2005;44:213–235
  29. Lewinsohn PM, Klein DN, Seeley JR. Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. Journal of the American Academy of Child and Adolescent Psychiatry. 1995;34:454–463
  30. Luby JL, Mrakotsky C. Depressed preschoolers with bipolar family history: a group at high risk for later switching to mania?. Journal of Child and Adolescent Psychopharmacology. 2003;13:187–197
  31. Luby JL, Heffelfinger AK, Mrakotsky C, Hessler MJ, Brown KM, Hildebrand T. Preschool major depressive disorder: preliminary validation for developmentally modified DSM-IV criteria [see comment]. Journal of the American Academy of Child and Adolescent Psychiatry. 2002;41:928–937
  32. Minde K. The use of psychotropic medication in preschoolers: some recent developments. Canadian Journal of Psychiatry-Revue Canadienne de Psychiatrie. 1998;43:571–575
  33. Pathak S, Arszman SP, Danielyan A, Johns ES, Smirnov A, Kowatch RA. Psychotropic utilization and psychiatric presentation of hospitalized very young children. Journal of Child and Adolescent Psychopharmacology. 2004;14:433–442
  34. Scheffer RE, Niskala Apps JA. The diagnosis of preschool bipolar disorder presenting with mania: open pharmacological treatment. Journal of Affective Disorders. 2004;82:S25–S34
  35. Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, et al. A children's global assessment scale (CGAS). Archives of General Psychiatry. 1983;40:1228–1231
  36. Soutullo CA, DelBello MP, Ochsner JE, McElroy SL, Taylor SA, Strakowski SM, et al. Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment. Journal of Affective Disorders. 2002;70:323–327
  37. Srinath S, Janardhan Reddy YC, Girimaji SR, Seshadri SP, Subbakrishna DK. A prospective study of bipolar disorder in children and adolescents from India. Acta Psychiatrica Scandinavica. 1998;98:437–442
  38. Strober M, Schmidt-Lackner S, Freeman R, Bower S, Lampert C, DeAntonio M. Recovery and relapse in adolescents with bipolar affective illness: a five-year naturalistic, prospective follow-up. Journal of the American Academy of Child and Adolescent Psychiatry. 1995;34:724–731
  39. Vitiello B. Pediatric psychopharmacology and the interaction between drugs and the developing brain. Canadian Journal of Psychiatry-Revue Canadienne de Psychiatrie. 1998;43:582–584
  40. Vitiello B. Psychopharmacology for young children: clinical needs and research opportunities. Pediatrics. 2001;108:983–989
  41. Weller RA, Weller EB, Tucker SG, Fristad MA. Mania in prepubertal children: has it been underdiagnosed?. Journal of Affective Disorders. 1986;11:151–154
  42. Weller EB, Weller RA, Danielyan AK. Mood disorders in prepubertal children. In:  Wiener J,  Dulcan M editor. The American Psychiatric Publishing Textbook of Child and Adolescent Psychiatry. Washington, DC: American Psychiatric Publishing, Incorporated; 2003;p. 411–435
  43. Weller EB, Weller RA, Lau KC, Weller AE, Danielyan AC, Zilber I. Diagnosing mania in children and adolescents. Biological Psychiatry. 2003;53:13S;(Supplement)
  44. Wozniak J, Biederman J. Childhood mania: insights into diagnostic and treatment issues. Journal of the Association for Academic Minority Physicians. 1997;8:78–84
  45. Wozniak J, Biederman J, Kiely K, Ablon JS, Faraone SV, Mundy E, et al. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children [see comments]. Journal of the American Academy of Child and Adolescent Psychiatry. 1995;34:867–876
  46. Wozniak J, Biederman J, Kwon A, Mick E, Faraone S, Orlovsky K, et al. How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates. Biological Psychiatry. 2005;58:583–588
  47. Zito JM, Safer DJ, dosReis S, Gardner JF, Boles M, Lynch F. Trends in the prescribing of psychotropic medications to preschoolers [see comment]. JAMA. 2000;283:1025–1030

PII: S0165-0327(06)00260-6

doi: 10.1016/j.jad.2006.05.028

Journal of Affective Disorders
Volume 97, Issue 1 , Pages 51-59 , January 2007

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