Journal of Affective Disorders
Volume 91, Issue 1 , Pages 83-86 , March 2006

Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients

  • Roberta Zanardini

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
  • ,
  • Anna Gazzoli

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
  • ,
  • Mariacarla Ventriglia

      Affiliations

    • AFaR-Department of Neurosciences, S.Giovanni Calibita-FBF, Isola Tiberina, Rome, Italy
  • ,
  • Jorge Perez

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
  • ,
  • Stefano Bignotti

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
  • ,
  • Paolo Maria Rossini

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
    • AFaR-Department of Neurosciences, S.Giovanni Calibita-FBF, Isola Tiberina, Rome, Italy
    • Neurology, University Campus Biomedico, Rome, Italy
  • ,
  • Massimo Gennarelli

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
    • Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy
  • ,
  • Luisella Bocchio-Chiavetto

      Affiliations

    • IRCCS “S. Giovanni di Dio”, Fatebenefratelli, Brescia, Italy
    • Corresponding Author InformationCorresponding author. Genetic Unit, I.R.C.C.S. “San Giovanni di Dio”-Fatebenefratelli, Via Pilastroni, 4, 25123 Brescia Italy. Tel.: +39 030 3501453; fax: +39 030 3533513.

Received 11 August 2005 ,Revised 9 December 2005 ,Accepted 14 December 2005.

References 

  1. Altar CA, Laeng P, Jurata LW, Brockman JA, Lemire A, Bullard J, et al. Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J. Neurosci. 2004;24:2667–2677
  2. Angelucci F, Brene S, Mathe AA. BDNF in schizophrenia, depression and corresponding animal models. Mol. Psychiatry. 2005;10:345–352
  3. Aydemir O, Deveci A, Taneli F. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2005;29:261–265
  4. Castren E. Neurotrophic effects of antidepressant drugs. Curr. Opin. Pharmacol. 2004;4:58–64
  5. Duman RS. Role of neurotrophic factors in the etiology and treatment of mood disorders. Neuromolecular Med. 2004;5:11–25
  6. George MS, Nahas Z, Lisanby SH, Schlaepfer T, Kozel FA, Greenberg BD. Transcranial magnetic stimulation. Neurosurg. Clin. N. Am. 2003;14:283–301
  7. Gonul, A.S., Akdeniz, F., Taneli, F., Donat, O., Eker, C., Vahip, S., 2005. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci. Published online April 2005
  8. Hashimoto K, Shimizu E, Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev. 2004;45:104–114
  9. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109:143–148
  10. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett. 2002;328:261–264
  11. Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry JM, Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol. Psychiatry. 2005;57:1068–1072
  12. Lisanby SH, Kinnunen LH, Crupain MJ. Applications of TMS to therapy in psychiatry. J. Clin. Neurophysiol. 2002;19:344–360
  13. Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol. Aging. 2005;26:115–123
  14. Miniussi C, Bonato C, Bignotti S, Gazzoli A, Gennarelli M, Pasqualetti P, et al. Repetitive transcranial magnetic stimulation (rTMS) at high and low frequency: an efficacious therapy for major drug-resistant depression?. Clin. Neurophysiol. 2005;116:1062–1071
  15. Muller MB, Toschi N, Kresse AE, Post A, Keck ME. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsychopharmacology. 2000;23:205–215
  16. Neumeister A, Yuan P, Young TA, Bonne O, Luckenbaugh DA, Charney DS, et al. Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects. Am. J. Psychiatry. 2005;162:805–807
  17. Padberg F, Moller HJ. Repetitive transcranial magnetic stimulation: does it have potential in the treatment of depression?. CNS Drugs. 2003;17:383–403
  18. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 1998;37:1553–1561
  19. Radka SF, Holst PA, Fritsche M, Altar CA. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res. 1996;709:122–301
  20. Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, et al Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr. Clin. Neurophysiol. 1994;91:79–92
  21. Russo-Neustadt AA, Chen MJ. Brain-derived neurotrophic factor and antidepressant activity. Curr. Pharm. Des. 2005;11:1495–1510
  22. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J. Neurosci. 2003;23:349–357
  23. Sairanen M, Lucas G, Ernfors P, Castren M, Castren E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J. Neurosci. 2005;25:1089–1094
  24. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol. Psychiatry. 2003;54:70–75
  25. Wassermann EM. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5–7, 1996. Electroencephalogr. Clin. Neurophysiol. 1998;108:1–16

PII: S0165-0327(05)00416-7

doi: 10.1016/j.jad.2005.12.029

Journal of Affective Disorders
Volume 91, Issue 1 , Pages 83-86 , March 2006