Journal of Affective Disorders
Volume 91, Issue 1 , Pages 39-44 , March 2006

Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder

  • Damiaan Denys

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author. UMC, (B.01.206), P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Tel.: +31 30 250 7472; fax: +31 30 250 5443.
    • ,
  • Filip Van Nieuwerburgh

      Affiliations

    • Laboratory of Pharmaceutical Biotechnology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    • ,
  • Dieter Deforce

      Affiliations

    • Laboratory of Pharmaceutical Biotechnology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    • ,
  • Herman G.M. Westenberg

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands

Received 5 November 2005 ,Revised 9 December 2005 ,Accepted 9 December 2005.

References 

  1. Adams BL, Warneke LB, McEwan AJ, Fraser BA. Single photon emission computerized tomography in obsessive compulsive disorder: a preliminary study. J. Psychiatry Neurosci. 1993;18(3):109–112
  2. Bengel D, Greenberg B, Cora-Locatelli G, Altemus M, Heils A, Li Q, et al. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive–compulsive disorder [In Process Citation]. Mol. Psychiatry. 1999;4(5):463–466
  3. Cavallini MC, Di Bella D, Siliprandi F, Malchiodi F, Bellodi L. Exploratory factor analysis of obsessive–compulsive patients and association with 5-HTTLPR polymorphism. Am. J. Med. Genet. 2002;114(3):347–353
  4. Delorme R, Betancur C, Callebert J, Chabane N, Laplanche JL, Mouren-Simeoni MC, et al. Platelet serotonergic markers as endophenotypes for obsessive–compulsive disorder. Neuropsychopharmacology. 2005;30(8):1539–1547
  5. Denys D, Zohar J, Westenberg HG. The Role of Dopamine in Obsessive–Compulsive Disorder: Preclinical and Clinical Evidence. J. Clin. Psychiatry. 2004;65(Suppl. 14):11–17
  6. Di Bella D, Erzegovesi S, Cavallini MC, Bellodi L. Obsessive–Compulsive Disorder, 5-HTTLPR polymorphism and treatment response. Pharmacogenomics J. 2002;2(3):176–181
  7. Enoch M, Greenberg BD, Murphy DL, Goldman D. Sexually dimorphic relationship of a 5-HT(2A) promoter polymorphism with obsessive–compulsive disorder. Biol. Psychiatry. 2001;49(4):385–388
  8. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale–Brown obsessive compulsive scale: I. Development, use, and reliability. Arch. Gen. Psychiatry. 1989;46(11):1006–1011
  9. Grados MA, Walkup J, Walford S. Genetics of obsessive-compulsive disorders: new findings and challenges. Brain Dev. 2003;25(Suppl. 1):S55–S61
  10. Hamilton M. The assessment of anxiety states by rating. Br. J. Med. Psychol. 1959;32:50–55
  11. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry. 1960;23:56–62
  12. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002;297(5580):400–403
  13. Hudziak JJ, Van Beijsterveldt CE, Althoff RR, Stanger C, Rettew DC, Nelson EC, et al. Genetic and environmental contributions to the Child Behavior Checklist Obsessive–Compulsive Scale: a cross-cultural twin study. Arch.Gen.Psychiatry. 2004;61(6):608–616
  14. Lochner C, Hemmings SM, Kinnear CJ, Niehaus DJ, Nel DG, Corfield VA, et al. Cluster analysis of obsessive–compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates. Compr. Psychiatry. 2005;46(1):14–19
  15. McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol. Psychiatry. 1998;3(3):270–273
  16. Munafo MR, Clark TG, Roberts KH, Johnstone EC. Neuroticism Mediates the Association of the Serotonin Transporter Gene with Lifetime Major Depression. Neuropsychobiology. 2005;53(1):1–8
  17. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ, Liang KY, et al. Complex segregation analysis provides compelling evidence for a major gene underlying obsessive–compulsive disorder and for heterogeneity by sex. Am. J. Hum. Genet. 2000;67(6):1611–1616
  18. Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive–compulsive disorder. Am. J. Psychiatry. 1995;152(1):76–84
  19. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry. 1998;59(Suppl. 20):22–33
  20. Smith GS, Lotrich FE, Malhotra AK, Lee AT, Ma Y, Kramer E, et al. Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology. 2004;29(12):2226–2234
  21. Stengler-Wenzke K, Muller U, Angermeyer MC, Sabri O, Hesse S. Reduced serotonin transporter-availability in obsessive–compulsive disorder (OCD). Eur. Arch. Psychiatry Clin. Neurosci. 2004;254(4):252–255
  22. Veenstra-VanderWeele J, Anderson GM, Cook EH. Pharmacogenetics and the serotonin system: initial studies and future directions. Eur. J. Pharmacol. 2000;410(2–3):165–181
  23. Walitza S, Wewetzer C, Warnke A, Gerlach M, Geller F, Gerber G, et al. 5-HT(2A) promoter polymorphism –1438G/A in children and adolescents with obsessive–compulsive disorders. Mol. Psychiatry. 2002;7(10):1054–1057
  24. Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, et al. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology. 2003;28(3):533–541
  25. Zohar J, Gross-Isseroff R, Hermesh H, Weizman A. Is there sexual dimorphism in obsessive–compulsive disorder?. Neurosci. Biobehav. Rev. 1999;23(6):845–849

PII: S0165-0327(05)00382-4

doi: 10.1016/j.jad.2005.12.011

Journal of Affective Disorders
Volume 91, Issue 1 , Pages 39-44 , March 2006

Article Tools