Journal of Affective Disorders
Volume 90, Issue 1 , Pages 43-47 , January 2006

Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients

  • Helen Cristina Miranda

      Affiliations

    • Department of Pathological Sciences-Immunology, Londrina State University, Londrina, PR, Brazil
    • ,
  • Sandra Odebrecht Vargas Nunes

      Affiliations

    • Department of Medical Clinic-Psychiatry, Londrina State University, Londrina, PR, Brazil
    • ,
  • Eberson Sanches Calvo

      Affiliations

    • Tropical Melhoramento e Genética Ltda, Cambé, PR, Brazil
    • ,
  • Sérgio Suzart

      Affiliations

    • Department of Microbiology, Londrina State University, Londrina, PR, Brazil
    • ,
  • Eiko Nakagawa Itano

      Affiliations

    • Department of Pathological Sciences-Immunology, Londrina State University, Londrina, PR, Brazil
    • ,
  • Maria Angelica Ehara Watanabe

      Affiliations

    • Department of Pathological Sciences-Immunology, Londrina State University, Londrina, PR, Brazil
    • Corresponding Author InformationCorresponding author. Universidade Estadual de Londrina, Campus Universitário, Departamento de Ciências Patológicas, Rod. Celso Garcia Cid (PR 445) Km 380, CEP 86051-970, Brazil. Tel./fax: +55 43 3371 5728.

Received 19 May 2005 ,Revised 8 October 2005 ,Accepted 13 October 2005.

References 

  1. Amsterdam J, Winokur A, Dyson W, Herzog S, Gonzales F, Rott R, et al. Borna disease virus. A possible etiologic factor in human Affective Disorders?. Arch. Gen. Psychiatry. 1985;42:1093–1096
  2. Bode L, Riegel S, Lange W, Ludwig H. Human infections with Borna disease virus: seroprevalence in patients with chronic disease and healthy individuals. J. Med. Virol. 1992;36:309–315
  3. Bode L, Ferzt R, Czech G. Borna disease virus infection and disorders in man. Arch. Virol. 1993;7:159–167
  4. Bode L, Zimmerman W, Ferszt R, Steinbach F, Ludwig H. Borna disease virus genome transcribed and expressed in psychiatric patients. Nat. Med. 1995;1(3):232–236
  5. Bode L, Reckwarld P, Everus W, Stoyloff R, Ferszt R. Borna disease virus-specific circulating immune complexes antigenemia, and free antibodies—the key marker triplet determining infection and prevailing in severe mood disorders. Mol. Psychiatry. 2001;6:481–491
  6. Chalmers RM, Thomas DRh, Salmon RL. Borna disease virus and the evidence for human pathogenicity: a systematic review. QJM. 2005;98:255–274
  7. Chen C, Chiu Y, Shaw C, Tsai M, Hwang A, Hsiao K. Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers. Mol. Psychiatry. 1999;4(6):566–571
  8. Dauphin G, Legay V, Pitel PH, Zientara S. Borna disease: current knowledge and virus detection in France. Vet. Res. 2002;33(2):127–138
  9. de la Torre JC. Bornavirus and the brain. J. Infect. Dis. 2002;1;186(Suppl. 2):S241–S247
  10. de la Torre JC, Gonzalez-Dunia D, Cubitt B, Mallory M, Mueller-Lantzsch N, Graesser FA. Detection of Borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. Virology. 1996;223:272–282
  11. Del Ben C, Vilela J, Crippa J, Labate C, Zuardi A. Confiabilidade da ¨Entrevista Clínica Estruturada para o D.S.M.-IV¨ versão clínica traduzida para o português. Rev. Bras. Psiquiatr. 2001;23(3):156–159
  12. Fukuda K, Takahashi K, Iwata Y, Mori N, Gonda K, Ogawa T. Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. J. Clin. Microbiol. 2001;38(2):419–429
  13. Haga S, Yoshimura M, Motoi Y, Arima K, Aizawa T, Tashiro K, et al. Detection of Borna disease virus genome in normal human brain tissue. Brain Res. 1997;770:307–309
  14. Hans A, Bajramovic JJ, Syan S, Perret E, Dunia I, Brahic M, et al. Persistent, non-cytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis. FASEB J. 2004;
  15. Horning M, Lipkin I. Infectious and Immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses and animal models. Mental retardation and developmental disabilities. Res. Rev. 2001;7:200–210
  16. Ikuta K, Ibrahim MS, Kobayashi T, Tomonaga K. Borna disease virus and infection in humans. Front. Biosci. 2002;7:470–495
  17. Inoue H, Nojima H, Okayama H. High efficiency transformation of Escherichia Coli with plasmids. Gene. 1990;96:23–28
  18. Iwata Y, Takahashi K, Peng X. Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. J. Virol. 1998;72(12):10044–10049
  19. Kishi M, Nakaya T, Nakamura Y, Zhong Q, Ikeda K, Senjo M, et al. Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells. FEBS Lett. 1995;364:293–297
  20. Lieb K, Hallensleben W, Czygan M, Stitz L, Starheli P. No Borna disease virus-specific RNA detected in blood from psychiatric patients from different regions of Germany. Lancet. 1997;350:1002
  21. Nakamura Y, Takahashi H, Shoya Y, Nakaya T, Watanabe M, Tomonaga K, et al. Isolation of Borna disease virus from human brain tissue. J. Virol. 2000;74(10):4601–4611
  22. Okamoto M, Kagawa Y, Kamitani W, Hagiwara K, Kirisawa R, Iwai H, et al. Borna disease in a dog in Japan. J. Comp. Pathol. 2002;126(4):312–317
  23. Pletnikov MV, Moran TH, Carbone KM. Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. Front. Biosci. 2002;7:D593–D607
  24. Sauder C, Műller A, Cubitt B, Mayer J, Steinmetz J, Trabert W, et al. Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. J. Virol. 1996;70:7713–7724
  25. Schneider U, Kim R, Lipkin WI. Evidence for translation of the Borna disease virus G protein by leaky ribosomal scanning and ribosomal reinitiation. J. Virol. 1997;71(7):5614–5619
  26. Schneider U, Schwemmle M, Staeheli P. Genome trimming: a unique strategy for replication control employed by Borna disease virus. Proc. Natl. Acad. Sci. 2005;102(9):3441–3446
  27. Stitz L, Bilzer T, Planz O. The immunopathogenesis of Borna disease virus infection. Front. Biosci. 2002;7:541–555
  28. Taieb O, Baleyte JM, Mazet P, Fillet AM. Borna disease virus and psychiatry. Eur. Psychiatr. 2001;16:03–10
  29. Terayama H, Nishino Y, Kishi M, Ikuta K, Itoh M, Iwahashi K. Detection of anti-Borna disease virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. Psychiatry Res. 2003;120(2):201–206
  30. Thomas DR, Chalmers RM, Crook B, Stagg S, Thomas HV, Lewis G, et al. Borna disease virus and mental health: a cross-sectional study. QJM. 2005;98:247–254
  31. Tomonaga K. Virus-induced neurobehavioral disorders: mechanisms and implications. Trends Mol. Med. 2004;10:71–77
  32. Tomonaga K, Kobayashi T, Ikuta K. Molecular and cellular biology of Borna disease virus infection. Microbes Infect. 2002;4(4):491–500
  33. Waltrip RW, Buchanan RW, Summerfelt A. Borna disease virus and schizophrenia. Psychiatry Res. 1995;56(1):33–34

PII: S0165-0327(05)00300-9

doi: 10.1016/j.jad.2005.10.008

Journal of Affective Disorders
Volume 90, Issue 1 , Pages 43-47 , January 2006

Article Tools