Journal of Affective Disorders
Volume 87, Issue 1 , Pages 11-16 , July 2005

Gender, suicidality and bipolar mixed states in adolescents

  • Steven C. Dilsaver

      Affiliations

    • Community Mental Health Clinic, Rio Grande City, TX, USA
    • Merced Department of Mental Health, P.O. Box 839, Merced, California, USA
    • Corresponding Author InformationCorresponding author. Merced Department of Mental Health, P.O. Box 839, Merced, California, USA. Tel.: +1 209 722 4953; fax: +1 209 381 7511.
    • ,
  • Franco Benazzi

      Affiliations

    • E Hecker Outpatient Center, Ravenna, Italy
    • Department of Psychiatry, National Health Service, Forli, Italy
    • ,
  • Zoltan Rihmer

      Affiliations

    • National Institute for Psychiatry and Neurology, Budapest, Hungary
    • ,
  • Kareen K. Akiskal

      Affiliations

    • National Union of Depressive and Manic-Depressive Associations, Rennes, France
    • International Mood Disorders Program, La Jolla, CA, USA
    • ,
  • Hagop S. Akiskal

      Affiliations

    • National Union of Depressive and Manic-Depressive Associations, Rennes, France
    • International Mood Disorders Program, La Jolla, CA, USA
    • San Diego Veterans Administration Medical Center, USA

Received 5 December 2004 ,Accepted 10 February 2005.

References 

  1. Akiskal HS. Developmental pathways to bipolarity: are juvenile-onset depressions pre-bipolar?. J. Am. Acad. Child Adolesc. Psych. 1995;34:754–763
  2. Akiskal HS, Benazzi F. Family history validation of the bipolar nature of depressive mixed states. J. Affect. Disord. 2003;73:113–122
  3. Akiskal HS, Downs J, Jordon P, Watson S, Daugherty D, Pruitt DB. Affective disorders in the referred children of younger siblings of manic-depressives: mode of onset and prospective course. Arch. Gen. Psychiatry. 1985;42:996–1003
  4. Akiskal HS, Hantouche EG, Bourgeois ML, Azorin JM, Sechter D, Allilaire JF, et al. Gender, temperament, and the clinical picture in dysphoric mixed mania: findings from a French national study (EPIMAN). J. Affect. Disord. 1998;50:175–186
  5. Akiskal HS, Benazzi F, Perugi G, Rihmer Z. Agitated “unipolar” depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy. J. Affect. Disord. 2005;85:245–258
  6. American Psychiatric Association Task Force on Nomenclature and Statistics. Diagnostic and Statistical Manual of the American Psychiatric Association. fourth edition, diagnostic edition. Washington, DC: American Psychiatric Association Press; 1984;
  7. Beautrais AL. Suicide and serious suicide attempts in youth: a multiple-group comparison study. Am. J. Psychiatry. 2003;160:1093–1099
  8. Benazzi F. Depression with racing thoughts. Psych. Res. 2003;120:273–282
  9. Benazzi F. Depressive mixed state: dimensional versus categorical definitions. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2003;27:129–134
  10. Carlson GA, Strober M. Affective disorder in adolescence: issues in misdiagnosis. J. Clin. Psychiatry. 1978;39:59–66
  11. Dilsaver SC, Chen YW, Swann AC, Shoaib AM, Tsai Y, Krajewski KJ. Suicidality in patients with pure and depressive mania. Am. J. Psychiatry. 1994;151:1312–1315
  12. Dilsaver SC, Chen YW, Swann AC, Shoaib AM, Tsai Y, Krajewski KJ. Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania. Psychiatry Res. 1997;73:47–56
  13. Dilsaver, S.C., Benazzi, F., Akiskal, H.S., in press. The mixed state: the most common outpatient presentation of bipolar depressed adolescents, Psychopathology.
  14. Dunner DL, Gershon ES, Goodwin FK. Heritable factors in the severity of affective illness. Biol. Psychiatry. 1976;11:31–42
  15. Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB. Treatment-emergent mania in pediatirc bipolar disorder: a retrospective chart review. J. Affect. Disord. 2004;82:149–158
  16. FDA: http://www.fda.gov/cder/drug/antidepressants/default.htm (accessed 29 November 2004).
  17. First MB, Gibbon M, Spitzer RC, Williams JBW, Benjamin LS. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID I), Clinician Version. Washington, DC: American Psychiatric Association Press; 1997;
  18. Geller B, Craney JL, Bolhofner K, Nickelsburg MJ, Williams M, Zimerman B. Two year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am. J. Psychiatry. 2002;159:927–933
  19. Goldberg JF, Garno JL, Leon AC, Kocsis JH, Portera L. Association of recurrent suicidal ideation with non-remission from acute mixed mania. Am. J. Psychiatry. 1998;155:1753–1755
  20. In:  Hawton K,  van Heeringen C editor. International Handbook of Suicide and Attempted Suicide. Chichester: John Wiley and Sons; 2000;
  21. Isometsa ET, Lönnqvist JK. Suicide attempts preceding completed suicide. Br. J. Psychiatry. 1998;173:531–535
  22. Kafantaris V, Coletti DJ, Dicker R, Padula G, Pleak RR, Alvir JMH, et al. Lithium treatment of acute mania in adolescents: a placebo-controlled discontinuation study. J. Am. Acad. Child Adolesc. Psych. 2004;43:984–993
  23. Maj M, Pirozzi R, Magliano L, Bartoli L. Agitated depression in bipolar I disorder: prevalence, phenomenology, and outcome. Am. J. Psychiatry. 2003;160:2134–2140
  24. Sato T, Bottlender R, Schroeter A, Moller HJ. Frequency of manic symptoms during a depressive episode and unipolar depressive mixed state' as bipolar spectrum. Acta Psychiatr. Scand. 2003;107:268–274
  25. Strakowski SM, McElroy SL, Keck PE, West SA. Suicidality among patients with mixed and manic bipolar disorder. Am. J. Psychiatry. 1996;153:674–676
  26. Voluck RJ, Libby AM, Sills MR, Griese AA, Allen RR. Antidepressant treatment and risk of suicide attempt by adolescents with major depressive disorder: a propensity-adjusted retrospective cohort study. CNS Drugs. 2004;18:1119–1132
  27. Wilens TE, Biederman J, Kwon A, Chase R, Greenberg L, Mick E, et al. A systematic chart review of the nature of psychiatric adverse effects in children and adolescents treat with selective serotonin reuptake inhibitors. J. Child Adolesc. Psychopharmacol. 2003;13:143–152
  28. Wunderlich U, Bronisch T, Wittchen H-U, Carter R. Gender differences in adolescents and young adults with suicidal behaviour. Acta Psychiatr. Scand. 2001;104:332–339

PII: S0165-0327(05)00045-5

doi: 10.1016/j.jad.2005.02.003

Journal of Affective Disorders
Volume 87, Issue 1 , Pages 11-16 , July 2005

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