Journal of Affective Disorders
Volume 83, Issue 1 , Pages 21-31 , 15 November 2004

Affective modulation of the startle response in depression: influence of the severity of depression, anhedonia, and anxiety

  • H. Kaviani

      Affiliations

    • Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    • Department of Psychiatry and Clinical Psychology, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • J.A. Gray

      Affiliations

    • This article is dedicated to the memory of Professor Jeffrey A. Gray, who passed away on 30th April 2004.
    • Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    • ,
  • S.A. Checkley

      Affiliations

    • Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    • ,
  • P.W. Raven

      Affiliations

    • Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, Royal Free Campus, London NW3 2PF, UK
    • ,
  • G.D. Wilson

      Affiliations

    • Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    • ,
  • V. Kumari

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Psychology, Institute of Psychiatry, De Crespigny Park, PO78, London SE5 8AF, UK. Tel.: +44-207-848-0233; fax: +44-207-848-0646.
    • Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

Received 16 January 2004 ,Revised 20 April 2004 ,Accepted 23 April 2004.

References 

  1. Abduljawad KA, Langley RW, Bradshaw CM, Szabadi E. Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man. J. Psychopharmacol. 1997;11(1):29–34
  2. Abduljawad KA, Langley RW, Bradshaw CM, Szabadi E. Effects of bromocriptine and haloperidol on prepulse inhibition of the acoustic startle response in man. J. Psychopharmacol. 1998;12(3):239–245
  3. Allen NB, Trinder J, Brennan C. Affective startle modulation in clinical depression: preliminary findings. Biol. Psychiatry. 1999;46:542–550
  4. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th Ed.. DSM. vol. IV. Washington DC: Author; 1994;
  5. Baas JM, Grillon C, Bocker KB, Brack AA, Morgan CA, Kenemans JL, et al. Benzodiazepines have no effect on fear-potentiated startle in humans. Psychopharmacology. 2002;161(3):233–247
  6. Bassareo V, Di Chiara G. Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments. Neuroscience. 1999;89(3):637–641
  7. Beck AT, Steer RA. Beck Depression Inventory. San Antonio: Harcourt Brace Janovich; 1987;
  8. Bradley MM, Codispoti M, Cuthbert BN, Lang PJ. Emotion and motivation: I. Defensive and appetitive reactions in picture processing. Emotion. 2001;3:276–298
  9. Boyer P, Tassin JP, Falissart B, Troy S. Sequential improvement of anxiety, depression and anhedonia with sertraline treatment in patients with major depression. J. Clin. Pharm. Ther. 2000;25(5):363–371
  10. Brown AS, Gershon S. Dopamine and depression. J. Neural Transm. 1993;91:75–109
  11. Carlson SR, Katsanis J, Iacono WG, McGue M. Emotional modulation of the startle reflex in twins: preliminary findings. Biol. Psychol. 1997;6(3):235–246
  12. Cassella JV, Davis M. Fear-enhanced acoustic startle is not attenuated by acute or chronic imipramine treatment in rats. Psychopharmacology. 1985;87(3):278–282
  13. Chapman LJ, Chapman JP, Raulin ML. Scales for physical and social anhedonia. J. Abnorm. Psychol. 1976;8:374–382
  14. Davis M, Falls M, Campeau S, Kim M. Fear potentiated startle: a neural and pharmacological analysis. Behav. Brain Res. 1993;58:175–198
  15. Di Chiara G. Role of dopamine in the behavioural actions of nicotine related to addiction. Eur. J. Pharmacol. 2000;393(1–3):295–314
  16. Ebert D, Feistel H, Loew T, Pirner A. Dopamine and depression—striatal dopamine D2 receptor SPECT before and after antidepressant therapy. Psychopharmacology. 1996;126:91–94
  17. Ellwanger J, Geyer MA, Braff DL. The relationship of age to prepulse inhibition and habituation of the acoustic startle response. Biol. Psychol. 2003;62(3):175–195
  18. Fowles DC. Psychophysiology and psychopathology: a motivational approach. Psychophysiology. 1988;25:373–391
  19. Gehricke J, Shapiro D. Reduced facial expression and social context in major depression: discrepancies between facial muscle activity and self-reported emotion. Psychiatry Res. 2000;21, 95(2):157–167
  20. Graham SJ, Langley RW, Balboa VA, Bradshaw CM, Szabadi E. Effects of ketanserin and haloperidol on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response in man. J. Psychopharmacol. 2002;16(1):15–22
  21. Gray JA. Framework for a taxonomy of psychiatric disorder. In:  Van Goozen SHM,  Van de Poll NE,  Sergeant JA editor. Emotions: Essays on Emotion Theory. Hillsdale, NJ: Lawrence Erlbaum; 1994;p. 29–59
  22. Grillon C. Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology. Biol. Psychiatry. 2002;52(10):958–975
  23. Kaviani H, Gray JA, Checkley SA, Kumari V, Wilson GD. Modulation of the acoustic startle reflex by emotionally-toned film-clips. Int. J. Psychophysiol. 1999;32:47–54
  24. Kokkinidis L, McCarter BD. Behavioral evidence implicating dopamine in sensorimotor arousal and norepinephrine in the sedative effects of antidepressant drugs. Psychopharmacology. 1990;100(4):527–542
  25. Koch M, Schmid A, Schnitzler HU. Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens. NeuroReport. 1996;7(8):1442–1446
  26. Kumari V, Cotter PA, Corr P, Gray JA, Checkley SA. Effect of clonidine on the human acoustic startle reflex. Psychopharmacology. 1996;123:353–360
  27. Kumari V, Mulligan OF, Cotter PA, Poon L, Toone BK, Checkley SA, et al. Effects of single oral administrations of haloperidol and d-amphetamine on prepulse inhibition of the acoustic startle reflex in healthy male volunteers. Behav. Pharmacol. 1998;9(7):567–576
  28. Kumari V, Kaviani H, Raven PW, Gray JA, Checkley SA. Enhanced startle reactions to acoustic stimuli in patients with obsessive–compulsive disorder. Am. J. Psychiatry. 2001;158:134–136
  29. Lader M. Anxiety and depression. In:  Gale A,  Edwards JA editor. Physiological Correlates of Human Behaviour. 3:London: Academic Press; 1983;p. 155–167
  30. Lang PJ, Bradley MM, Cuthbert BN, Patrick CJ. Emotion and psychopathology: a startle probe analysis. In:  Chapman LJ, et al. editor. Experimental Personality and Psychopathology Research. New York: Springer; 1993;p. 163–199
  31. Lemke MR, Puhl P, Koethe N, Winkler T. Psychomotor retardation and anhedonia in depression. Acta Psychiatr. Scand. 1999;99(4):252–256
  32. Mayberg H. Limbic-cortical dysregulation: a proposed model of depression. J. Neuropsychiatry. 1997;9:471–481
  33. Naranjo CA, Tremblay LK, Busto UE. The role of the brain reward system in depression. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2001;25(4):781–823
  34. Nelson JC, Charney DS. The symptoms of major depressive illness. Am. J. Psychiatry. 1981;138:1–13
  35. Patrick CJ, Bradley M, Lang PJ. Emotion in the criminal psychopath: startle reflex modification. J. Abnorm. Psychology. 1993;102:82–92
  36. Patrick CJ, Berthot BD, Moore DL. Diazepam blocks fear-potentiated startle in humans. J. Abnorm. Psychology. 1996;105:89–96
  37. Parker G, Hadzi-Pavlovic D. Melancholia: a Disorder of Movement. Cambridge: Cambridge Univ. Press; 1996;
  38. Phillips MA, Langley RW, Bradshaw CM, Szabadi E. The effects of some antidepressant drugs on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response in man. J. Psychopharmacol. 2000;14(1):40–45
  39. Pastor MC, Molto J, Vila J, Lang PJ. Startle reflex modulation, affective ratings and autonomic reactivity in incarcerated Spanish psychopaths. Psychophysiology. 2003;40(6):934–948
  40. Riba J, Rodriguez-Fornells A, Urbano G, Morte A, Antonijoan R, Barbanoj MJ. Differential effects of alprazolam on the baseline and fear-potentiated startle reflex in humans: a dose–response study. Psychopharmacology. 2001;157(4):358–367
  41. Sheline YI. Neuroimaging studies of mood disorder effects on the brain. Biol. Psychiatry. 2003;54(3):338–352
  42. Snaith P. Anhedonia: a neglected symptom of psychopathology. Psychol. Med. 1993;23:957–966
  43. Vrana SR, Spence EL, Lang PJ. The startle probe response: a new measure of emotion?. J. Abnorm. Psychology. 1988;97:487–491
  44. Wexler BE, Levenson L, Warrenburg S, Price LH. Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psych. Res. 1994;51:127–138
  45. Willner P. Dopaminergic mechanisms in depression and mania. In:  Bloom FE,  Kupfer DJ editor. Psychopharmacology: the Forth Generation of Progress. NY: Raven Press; 1995;p. 921–931
  46. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr. Scand. 1983;67:361–370

PII: S0165-0327(04)00170-3

doi: 10.1016/j.jad.2004.04.007

Journal of Affective Disorders
Volume 83, Issue 1 , Pages 21-31 , 15 November 2004

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