Journal of Affective Disorders
Volume 82, Issue 3 , Pages 443-446 , 1 November 2004

Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations

  • Margareta Reis

      Affiliations

    • Corresponding Author InformationCorresponding author. Institute of Laboratory Medicine, Department of Clinical and Experimental Pharmacology, Lund University Hospital, SE 221 85 Lund, Sweden. Tel.: +46-703-20-00-04; fax: +46-46-211-1987.
    • Division of Clinical Pharmacology, Linköping University, Linköping, Sweden
    • Department of Clinical and Experimental Pharmacology, Lund University, Lund, Sweden
    • ,
  • Anna Åberg-Wistedt

      Affiliations

    • Karolinska Institute, Department of Psychiatry, Stockholm, Sweden
    • ,
  • Hans Ågren

      Affiliations

    • Karolinska Institute, Neurote Department, Division of Psychiatry, Huddinge, Sweden
    • ,
  • Ann-Charlotte Åkerblad

      Affiliations

    • Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
    • ,
  • Finn Bengtsson

      Affiliations

    • Division of Clinical Pharmacology, Linköping University, Linköping, Sweden
    • Department of Clinical and Experimental Pharmacology, Lund University, Lund, Sweden

Received 1 May 2003 ,Revised 16 February 2004 ,Accepted 16 February 2004.

References 

  1. Åberg-Wistedt A, Ågren H, Ekselius L, Bengtsson F, Åkerblad AC. Sertraline versus paroxetine in major depression: clinical outcome after six months of continuous therapy. J. Clin. Psychopharmacol. 2000;20:645–652
  2. Björk H, Bengtsson F. A simple method for routine TDM of the SSRI sertraline and desmethylsertraline in serum by HPLC. Eur. J. Clin. Pharmacol. 1997;52:A156
  3. Cramer JA. Medication compliance in epilepsy. Arch. Intern. Med. 1991;151:1236–1237
  4. Demyttenaere K, Mesters P, Boulanger B, Dewe W, Delsemme MH, Gregoire J, et al. Adherence to treatment regimen in depressed patients treated with amitriptyline or fluoxetine. J. Affect. Disord. 2001;65:243–252
  5. Lingam R, Scott J. Treatment non-adherence in affective disorders. Acta Psychiatr. Scand. 2002;105:164–172
  6. Perel JM. Compliance during tricyclic antidepressant therapy: pharmacokinetic and analytical issues. Clin. Chem. 1988;34:881–887
  7. Peveler R, George C, Kinmonth AL, Campbell M, Thompson C. Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial. BMJ. 1999;319:612–615
  8. Pullar T, Kumar S, Tindall H, Feely M. Time to stop counting the tablets?. Clin. Pharmacol. Ther. 1989;46:163–168
  9. Rudd P, Byyny RL, Zachary V, LoVerde ME, Titus C, Mitchell WD, et al. The natural history of medication compliance in a drug trial: limitations of pill counts. Clin. Pharmacol. Ther. 1989;46:169–176

PII: S0165-0327(04)00078-3

doi: 10.1016/j.jad.2004.02.003

Journal of Affective Disorders
Volume 82, Issue 3 , Pages 443-446 , 1 November 2004

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