“Coping with depression”: an open study of the efficacy of a group psychoeducational intervention in chronic, treatment-refractory depression

Abstract 

Background: Failure to respond to antidepressant medication represents a major clinical problem. Few therapeutic interventions have been shown to benefit such individuals. Method: Patients attended a 12-session psychoeducational programme over a period of 10 weeks, with follow-up at 26 weeks. The main outcome measures were the self-report Beck Depression Inventory (BDI-II), the Global Severity Index (GSI) of the Brief Symptom Inventory (BSI) and the EuroQol 5D. Results: Baseline assessments confirmed substantial chronicity and treatment resistance, high symptom burden and poor quality of life in the study cohort. Twenty-six week follow-up data were obtained from 34% of cohort. Completion of the course was associated with clinically significant changes in symptom burden. Sustained remission was achieved by 35% of completers. Limitations: We did not characterise the cohort using structured clinical interview and did not collect structured, objective ratings of mental health status. There was no control group. There was a high attrition rate and caution must be exercised in interpreting results. Conclusions: For a proportion of patients with chronic depressive episodes that have not responded to antidepressant treatments, the “Coping with Depression” psychoeducational group may confer sustained and meaningful benefit. Controlled studies are warranted.

Keywords:  Depression, Chronic, Treatment refractory, Psychoeducational, “Coping with depression”