Journal of Affective Disorders
Volume 77, Issue 1 , Pages 1-9 , October 2003

Recognition of childhood depression: Personal reminiscences

Received 19 April 2002 ,Accepted 13 February 2003.

References 

  1. Akiskal HS, Downs J, Jordan P, Watson S, Daugherty D, Pruitt DB. Affective disorders in the referred children and younger siblings of manic–depressives: mode of onset and prospective course. Arch. Gen. Psychiatry. 1985;42:996–1003
  2. Akiskal HS. Developmental pathways to bipolarity: are juvenile-onset depressions pre-bipolar?. J. Am. Acad. Child Adolesc. Psychiatry. 1995;34:754–763
  3. Akiskal HS. Current issues in childhood bipolarity. J. Affect. Disord. 1998;51:75–76
  4. Anthony J, Scott PD. Manic–depressive psychosis in childhood. J. Child Psychol. Psychiatry. 1960;1:53–72
  5. Arietti S. American Handbook of Psychiatry. New York: Basic Books; 1959;
  6. Bakwin H. Emotional deprivation in infants. J. Pediatr. 1949;35:512–521
  7. Biederman J, Mick E, Faraone SV, Spencer T, Wilens TE, Wozniak J. Pediatric mania: a developmental subtype of bipolar disorder?. Biol. Psychiatry. 2000;48:458–466
  8. Birmaher B, Ryan ND, Williamson DE, Brent DA, Kaufman J, Dahl RE, et al. Childhood and adolescent depression: a review of the past 10 years. J. Am. Acad. Child Adolescent Psychiatry. 1996;35:1427–1439
  9. Bowby J. Attachment and Loss. I. London: Hogarth Press; 1969;
  10. Cantwell DP. The diagnostic process and diagnostic classification in child psychiatry—DSM-III. J. Am. Acad. Child Psychiatry. 1980;19:345–355
  11. Carlson GA, Strober M. Manic-depressive illness in early adolescence: a study of clinical and diagnostic characteristics in six cases. J. Am. Acad. Child Psychiatry. 1978;17:138–153
  12. Carlson GA, Cantwell DP. Unmasking masked depression in children and adolescents. Am. J. Psychiatry. 1980;137:445–449
  13. Carlson GA, Bromet EJ, Driessens C, Schwartz JE. Age at onset, childhood psychopathology, and 2-year outcome in psychotic bipolar disorder. Am. J. Psychiatry. 2002;159:307–309
  14. Charny CW. The spermatogenic potential of the undescended testis before and after treatment. J. Urol. 1960;83:697–705
  15. Connolly NK. Maldescent of testis. Amer. Surg. 1959;25:405–420
  16. Cramer JB. Common neuroses in childhood. In:  Arietti S editors. American Handbook of Psychiatry. New York: Basic Books; 1959;
  17. Cytryn L, Cytryn E, Rieger R. Psychological implications of cryptorchism. J. Am. Acad. Child Psychiatry. 1967;6:131–165
  18. Cytryn L. Factors in the psychological adjustment of children with chronic illness and handicaps. Clinical Proceedings of Children’s Hospital, Washington, DC. 1971;28:85–90
  19. Cytryn L, McKnew DH. Proposed classification of childhood depression. Am. J. Psychiatry. 1972;129:149–155
  20. Cytryn L, Moore PV, Robinson ME. Psychological adjustment of children with cystic fibrosis. In:  Anthony EJ,  Koupernick LC editor. The Child and His Family. New York: Wiley; 1973;
  21. Cytryn L, McKnew DH, Logue M, Desai RB. Biochemical correlations of affective disorders in children. Arch. Gen. Psychiatry. 1974;31:659–661
  22. Cytryn L. Studies of behavior in children with Down’s children. In:  Anthony EJ editors. Explorations in Child Psychiatry. New York: Plenum; 1975;
  23. Cytryn, L., McKnew, D.H., 1979. Affective disorders of childhood. In: Noshpitz, J. (Ed.), Basic Handbook of Child Psychiatry. Basic Books, New York, pp. 321–340.
  24. Cytryn L, McKnew DH. Affective disorders in childhood. In:  Kaplan HI,  Friedman AM,  Sadock BJ editor. Comprehensive Textbook of Psychiatry. Third Edition. Baltimore, London: Williams & Wilkins; 1980;p. 2798–2809
  25. Cytryn L, McKnew DH, Bunney WJ. Diagnosis of depression in children: a reassessment. Am. J. Psychiatry. 1980;137:22–25
  26. Cytryn L, McKnew DH, Bartko JJ, Lamour M, Hamovit J. Offspring of patients with affective disorders II. J. Am. Acad. Child Psychiatry. 1982;21:389–391
  27. Cytryn L, Mckew DH, Zahn-Waxler C, Radke-Yarrow M, Geansbauer TJ, Harmon RJ, et al. A developmental view of affective disturbances in children of affectively ill parents. Am. J. Psychiatry. 1984;141:219–222
  28. Cytryn L, McKnew DH, Zahn-Wachsler C, Gershon ES. Developmental issues in risk research: the offspring of affectively ill parents. In:  Rutter M,  Izard CR,  Read PB editor. Depression in Young People. New York, London: Guilford Press; 1986;p. 163–188
  29. Duffy A, Alda M, Kutcher S, Fusee C, Grof P. Psychiatric symptoms and syndromes among adolescent children of parents with lithium-responsive or lithium-nonresponsive bipolar disorder. Am. J. Psychiatry. 1998;155:431–433
  30. Engel GL. Anxiety and depression withdrawal: The primary affects of displeasure. Internat. J. Psychoanal. 1962;43:89
  31. Feighner JP, Robins E, Guze SP, Woodruff RA, Winokur G, Munoz R. Diagnostic criteria for use in psychiatric research. Arch. Gen. Psychiatry. 1972;26:57–63
  32. In:  Friedman AM,  Kaplan HL editor. Comprehensive Textbook of Psychiatry. Baltimore, London: Williams & Wilkins; 1967;
  33. In:  Friedman AM,  Kaplan HL editor. Comprehensive Textbook of Psychiatry. Second Edition. Baltimore, London: Williams & Wilkins; 1975;
  34. Geansbauer TJ, Harmon RJ, Cytryn L, McKnew DH. Social and affective development in infants with a manic–depressive parent. Am. J. Psychiatry. 1984;141:223–229
  35. Geller B, Craney JL, Bolhofner K, Nickelsburg MJ, Williams M, Zimerman B. Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am. J. Psychiatry. 2002;159:927–933
  36. Harrington R, Fudge H, Rutter M, Pickles A, Hill J. Child and adult depression: a test of continuities with data from a family study. Br. J. Psychiatry. 1993;162:627–633
  37. Hodges K, Klein J, Stern L, McKnew DH, Cytryn L. The development of a child assessment interview for research and clinical use. J. Abnorm. Child Psychology. 1982;10:73
  38. Kanner, L., 1957. Child Psychiatiy. Springfield, IL.
  39. Kashani, J., Hussain, A., Shekim, W.O., Hodges, K., Cytryn, L., McKnew, Jr., 1981. Current perspective on childhood depression: An overview. Am. J. Psychiatry 138, 143–154.
  40. Kovacs M, Beck AT. An empirical–clinical approach toward a definition of childhood depression. In:  Schultenbrand JG,  Raskin A editor. Depression in Childhood: Diagnosis, Treatment and Conceptual Models. New York: Raven Press; 1977;
  41. Kovacs M, Akiskal HS, Gatsonis C, Parrone PL. Childhood-onset dysthymic disorder: clinical features and prospective naturalistic outcome. Arch. Gen. Psychiatry. 1994;51:365–374
  42. Kovacs M. Presentation and course of major–depressive reaction during childhood and later years of the life span. J. Am. Acad. Child Adolesc. Psychiatry. 1996;35:705–715
  43. Maas JW, Dekermenjian H, Fawcett J. Catecholamine metabolism, depression and stress. Nature (Lond.). 1971;230:330–331
  44. Mahler MS. On sadness and grief in infancy and childhood. Psychoanal. Study Child. 1961;16:332–354
  45. Malmquist, C., 1971. Depression in childhood and adolescence. New Eng. J. Med., 284, 218–237, 887–892.
  46. Masi G, Toni C, Perugi G, Mucci M, Millepiedi S, Akiskal H. Anxiety disorders in consecutively referred children and adolescents with bipolar disorder: a neglected comorbidity. Can. J. Psychiatry. 2001;46:797–802
  47. McKnew DH, Cytryn L. Historical background of children with affective disorders. Am. J. Psychiatry. 1973;130:1278–1279
  48. McKnew DH, Cytryn L, White I. Clinical and biochemical correlates of hypomania in a child. J. Am. Acad. Child Psychiatry. 1974;13:576–585
  49. McKnew DH, Cytryn L. Urinary metabolites in chronically depressed children. J. Am. Acad. Child Psychiatry. 1979;18:148–152
  50. McKnew DH, Cytryn L, Efron AM, Gershon ES, Bunney WE. Offspring of manic–depressive patients. Br. J. Psychiatry. 1979;134:148–152
  51. McKnew DH, Cytryn L, Rapoport J, Buchsbaum M, Gershon E, Lamour M, et al. Lithium in children of lithium-responding parents. Psychiatry Res. 1981;2:171–180
  52. Pfeffer CR. Suicide in mood disordered children and adolescents. Child Adolesc. Psychiatr. Clin. N. Am. 2002;11:639–647
  53. Poznanski E, Zrull J. Childhood depression: Clinical characteristics of depressed children. Arch. Gen. Psychiatry. 1970;2:8–15
  54. Puig-Antich J, Blau S, Marx J, Greenhill LL, Chambers W. Pre-pubertal major depressive disorder: a pilot study. J. Am. Acad. Child Psychiatry. 1978;17:695–707
  55. Radke-Yarrow M, Nottelmann E, Martinez P, Fox MB, Belmont B. Young children of affectively ill parents: a longitudinal study of psychosocial development. J. Am. Acad. Child Adolesc. Psychiatry. 1992;31:68–77
  56. Radke-Yarrow M, Nottelmann E, Belmont B, Welsh JD. Affective interactions of depressed and nondepressed mothers and their children. J. Abnorm. Child Psychol. 1993;21:683–695
  57. Rie HE. Depression in childhood: A survey of some pertinent contributions. J. Am. Acad. Child Psychiatry. 1966;5:653–685
  58. Rochlin G. The loss complex. J. Am. Psychoanal. Assn. 1959;7:229–316
  59. Schildkraut JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am. J. Psychiatry. 1965;122:509–522
  60. Schildkraut JJ. Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: preliminary findings. Am. J. Psychiatry. 1973;132:695–699
  61. Spitz RA, Wolf KM. Anaclitic depression: An inquiry into the genesis of psychiatric conditions in early childhood. Psychoanalytic Study of Child. 1946;24:313–342
  62. Weinberg WA, Rutman J, Sullivan L, Pennick BC, Deitz SG. Depression in children referred to an educational diagnostic center: Diagnosis and treatment. J. Pediatr. 1973;83:1065–1072
  63. Weissman MM, Wolk S, Wickamaratne PJ, et al.  Children with prepubertal-onset depressive and anxiety disorders-grown up. Arch. Gen. Psychiatry. 1999;56:794–801
  64. Weller RA, Weller EB, Tucker SG, Fristad MA. Mania in prepubertal children: has it been underdiagnosed?. J. Affect. Disord. 1986;11:151–154
  65. Weller RA, Kapadia P, Weller EB, Fristad M, Lazaroff AB, Preskorn SH. Psychopathology in families of children with major depressive disorders. J. Affect. Disord. 1994;31:247–252
  66. Weller E, Weller R, Fristad MA. Bipolar disorder in children: misdiagnosis, underdiagnosis and future directions. J. Am. Acad. Child Adolesc. Psychiatry. 1995;34:709–714
  67. Zahn-Waxler C, McKnew DH, Cummings EM, Davenport YM, Radke-Yarrow M. Problem behaviors and peer interactions in young children with a manic–depressive parent. Am. J. Psychiatry. 1984;141:236–240
  68. Zahn-Waxler C, Mayfield A, Radke-Yarrow M, McKnew DH, Cytryn L, Davenport YB. A follow-up investigation of offspring of parents with bipolar disorder. Am. J. Psychiatry. 1988;145:506–509

 Editor’s note. We have published millennial reviews, articles, and special issues during the past several years reflecting key developments in affective disorders that have transformed our field. Certainly the field of affective disorders in children is one of these, important for genetics, clinical science, and public health. Leon Cytryn was one of the early pioneers whose work had a formative influence in shaping this field in the United States. By invitation, in this special article he provides us with personal reminiscences of the role he played in these developments. This article is intended to be for the historical memoir, as well as for the benefit of young investigators two or three generations after him, who will learn about the early struggles, hypotheses, and increments in knowledge leading to the growth of the overlapping fields of childhood depression and bipolar disorder. Although this memoir is largely focused on early work conducted by himself and his colleagues at George Washington University and at NIMH, Dr. Cytryn does briefly mention those whom he considers to be other major players who moved the field of juvenile affective disorders forward [HSA].

PII: S0165-0327(03)00048-X

doi: 10.1016/S0165-0327(03)00048-X

Journal of Affective Disorders
Volume 77, Issue 1 , Pages 1-9 , October 2003