Journal of Affective Disorders
Volume 74, Issue 3 , Pages 299-304 , May 2003

Depression in women with polycystic ovary syndrome: clinical and biochemical correlates

  • Natalie L. Rasgon

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-310-794-1478; fax: +1-310-794-9915
    • ,
  • Rekha C. Rao

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA
    • ,
  • Sun Hwang

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA
    • ,
  • Lori L. Altshuler

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA
    • ,
  • Shana Elman

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA
    • ,
  • Joni Zuckerbrow-Miller

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA
    • ,
  • Stanley G. Korenman

      Affiliations

    • Department of Medicine, Division of Endocrinology, University of California Los Angeles School of Medicine, Los Angeles, CA, USA

Received 6 September 2001 ,Accepted 17 January 2002.

References 

  1. Baischer W, Koinig G, Hartmann B, Huber J, Langer G. Hypothalamic–pituitary–gonadal axis in depressed premenopausal women: elevated blood testosterone concentrations compared to normal controls. Psychoneuroendocrinology. 1995;20(5):553–559
  2. Bruce-Jones W, Zolese G, White P. Polycystic ovary syndrome and psychiatric morbidity. J. Psychosom. Obstet. Gynecol. 1993;14:111–116
  3. Brunswick DJ, Frazer A, Koslow SH, Casper R, Stokes PE, Robins E, et al. Insulin-induced hypoglycemic response and release of growth hormone in depressed patients and healthy controls. Psychol. Med. 1988;18(1):79–91
  4. Chang RJ, Nakamura RM, Judd HL, Kaplan SA. Insulin resistance in nonobese patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab. 1983;57:356–369
  5. Chiba M, Suzuki S, Hinokio Y, Hirai M, Satoh Y, Tashiro A, et al.  Tyrosine hydroxylase gene microsatellite polymorphism associated with insulin resistance in depressive disorder. Metabolism: Clin. Exp. 2000;49:1145–1149
  6. Coyne JC, Fechner-Bates S, Schwenk TL. Prevalence, nature, and comorbidity of depressive disorders in primary care. Gen. Hosp. Psychiatry. 1994;16:267–276
  7. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 1989;38:1165–1174
  8. Fava GA, Grandi S, Savron G, Bartolucci G, Santarsiero G, Trombini G, et al.  Psychosomatic assessment of hirsute women. Psychother. Psychosom. 1989;51(2):96–100
  9. Figlewicz DP. Endocrine regulation of neurotransmitter transporters. Epilepsy Res. 1999;37(3):203–210
  10. Franks S. Polycystic ovary syndrome. New Engl. J. Med. 1995;333:853–861
  11. Futterweit W. CME review article 18: polycystic ovary syndrome: clinical perspectives and management. Obstet. Gynecol. Surv. 1999;54(6):403–413
  12. Gonzalez F. Adrenal involvement in polycystic ovary syndrome. Semin. Reprod. Endocrinol. 1997;15(2):137–157
  13. Horacek J, Kuzmiakova M, Hoschl C, Andel M, Bahbonh R. The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers. Psychoneuroendocrinology. 1999;24:785–797
  14. Istvan J, Zavela K, Weidner G. Body weight and psychological distress in NHANES I. Int. J. Obes. 1992;16:999–1003
  15. Judd L, Akiskal HS, Paulus MP. The role and clinical significance of subsyndromal depressive symptoms (SSD) in unipolar major depressive disorder. J. Affect. Disord. 1997;45:5–17
  16. Koslow SH, Stokes PE, Mendels J, Ramsey A, Casper R. Insulin tolerance test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects. Psychol. Med. 1982;12:45–55
  17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  18. McCarty MF. Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression–an adjuvant role for chromium picolinate?. Med. Hypotheses. 1994;43(4):247–252
  19. Menna-Perper M, Rochford J, Mueller PS, Swartzburg M, Jekelis AW, Manowitz P. Differential response of plasma glucose, amino acids and nonesterified fatty acids to insulin in depressed patients. Psychoneuroendocrinology. 1984;9(2):161–171
  20. Nathan RS, Sachar EJ, Asnis GM, Halbreich U, Halpern FS. Relative insulin insensitivity and cortisol secretion in depressed patients. Psychiatry Res. 1981;4(3):291–300
  21. Okamura F, Tashiro A, Utsumi A, Imai T, Suchi T, Hongo M. Insulin resistance in patients with depression and its changes in the clinical course of depression: a report on three cases using the minimal model analysis. Internal Med. 1999;38(3):257–260
  22. Okamura F, Tashiro A, Utsumi A, Imai T, Suchi T, Tamura D, et al. Insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis. Metabolism. 2000;49(10):1255–1260
  23. Patten SB, Lamarre CJ. Can drug-induced depressions be identified by their clinical features?. Can. J. Psychiatry. Revue Canadienne de Psychiatrie. 1992;37:213–215
  24. Rao RC, Rasgon NL, Hwang S, Altshuler LL, Zuckerbrow-Miller J, Korenman S. In: Prevalence of depression in women with polycystic ovary syndrome. Abstract, American Psychiatric Association, New Orleans, Louisiana, May. 2001;
  25. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Applied Psychol. Measur. 1977;1:385–401
  26. Rasgon NL, Altshuler LL, Gudeman D, Burt VK, Tanavoli S, Hendrick V, et al.  Medication status and PCO syndrome in women with bipolar disorder: a preliminary report. J. Clin. Psychiatry. 2000;61:173–178
  27. Schulberg HC, Saul M, McClelland M, Ganguli M, Christy W, Frank R. Assessing depression in primary medical and psychiatric practices. Arch. Gen. Psychiatry. 1985;42:1164–1170
  28. Shulman LH, DeRogatis L, Spielvogel R, Miller JL, Rose LI. Serum androgens and depression in women with facial hirsutism. J. Am. Acad. Dermatol. 1992;27:178–181
  29. Weber B, Lewicka S, Deuschle M, Colla M, Heuser I. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology. 2000;25:765–771
  30. Winokur A, Maislin G, Phillips JL, Amsterdam JD. Insulin resistance after oral glucose tolerance testing in patients with major depression. Am. J. Psychiatry. 1988;145(3):325–330
  31. Yen SSC. Chronic anovulation caused by peripheral endocrine disorders. In:  Yen SSC,  Jaffe RB editor. Reproductive Endocrinology: Physiology, Pathophysiology and Clin. Management. 3rd Edition. Philadelphia: W.B. Saunders; 1991;p. 576–630
  32. Zich JM, Attkisson CC, Greenfield TK. Screening for depression in primary care clinics: the CES-D and the BDI. Intl. J. Psychiatry Med. 1990;20(3):259–277

PII: S0165-0327(02)00117-9

doi: 10.1016/S0165-0327(02)00117-9

Journal of Affective Disorders
Volume 74, Issue 3 , Pages 299-304 , May 2003

Article Tools

* Image Usage & Resolution