Journal of Affective Disorders
Volume 76, Issue 1 , Pages 249-253, September 2003

Protein kinase A activity in platelets from patients with bipolar disorder

  • Daniela Tardito

      Affiliations

    • Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-02-5031-8331; fax: +39-02-5031-8278
    • ,
  • Silvia Mori

      Affiliations

    • Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    • ,
  • Giorgio Racagni

      Affiliations

    • Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    • ,
  • Enrico Smeraldi

      Affiliations

    • Istituto Scientifico HSR, Department of Neuropsychiatry, School of Medicine, Università Vita e Salute, Milan, Italy
    • ,
  • Raffaella Zanardi

      Affiliations

    • Istituto Scientifico HSR, Department of Neuropsychiatry, School of Medicine, Università Vita e Salute, Milan, Italy
    • ,
  • Jorge Perez

      Affiliations

    • Istituto Scientifico HSR, Department of Neuropsychiatry, School of Medicine, Università Vita e Salute, Milan, Italy

Received 14 December 2001; received in revised form 30 January 2002; accepted 4 February 2002.

Abstract 

Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

Keywords:  Bipolar disorder, PKA activity, cAMP signaling, Platelets

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PII: S0165-0327(02)00065-4

doi:10.1016/S0165-0327(02)00065-4

Journal of Affective Disorders
Volume 76, Issue 1 , Pages 249-253, September 2003

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