Journal of Affective Disorders
Volume 76, Issue 1 , Pages 49-54 , September 2003

A neuropathological study of periventricular white matter hyperintensities in major depression

  • Alan J. Thomas

      Affiliations

    • Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    • Corresponding Author InformationCorresponding author. Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK. Tel.: +44-191-2563-323; fax: +44-191-2195-051
    • ,
  • John T. O’Brien

      Affiliations

    • Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    • ,
  • Robert Barber

      Affiliations

    • Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    • ,
  • William McMeekin

      Affiliations

    • Department of Pathology, Newcastle General Hospital, Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    • ,
  • Robert Perry

      Affiliations

    • Department of Pathology, Newcastle General Hospital and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK

Received 24 November 2001 ,Revised 25 January 2002 ,Accepted 4 February 2002.

References 

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  5. de Groot JC, de Leeuw F, Oudkirk M, Hofman A, Jolles J, Breteler MB. Cerebral white matter lesions and depressive symptoms in elderly adults. Arch. Gen. Psychiatry. 2000;57:1071–1076
  6. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683–1689
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  10. O’Brien J, Perry R, Barber R, Gholkar A, Thomas A. The association between white matter lesions on magnetic resonance imaging and noncognitive symptoms. Ann. N.Y. Acad. Sci. 2000;903:482–489
  11. O’Brien JT, Ames D, Schwietzer I. White matter changes in depression and Alzheimer’s disease: a review of magnetic resonance imaging studies. Int. J. Ger. Psychiatry. 1996;11:681–694
  12. Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJ, Vermersch P, et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J. Neurol. Sci. 1993;114:7–12
  13. Stoll G, Jander S, Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 1998;56:149–171
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  15. Thomas AJ, Ferrier IN, Kalaria RN, Perry RH, Brown A, O’Brien JT. A neuropathological study of vascular factors in late-life depression. J. Neurol. Neurosurg. Psychiatry. 2001;70:83–87
  16. Thomas, A.J., O’Brien, J.T., Davis, S., Ballard, C., Barber, R., Kalaria, R., Perry, R.H., in press. Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. Arch. Gen. Psychiatry.
  17. van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain. 1991;114:761–774

PII: S0165-0327(02)00064-2

doi: 10.1016/S0165-0327(02)00064-2

Journal of Affective Disorders
Volume 76, Issue 1 , Pages 49-54 , September 2003

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