Journal of Affective Disorders
Volume 78, Issue 1 , Pages 21-26 , January 2004

QT dispersion in patients with social phobia

  • Eitan Nahshoni

      Affiliations

    • The Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Beilinson Campus, Rabin Medical Center, Petah Tikva, Israel 49100
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Shay Gur

      Affiliations

    • Anxiety Disorders and Behavior Therapy Unit, Psychiatric Outpatient Clinic, Geha Mental Health Center, Rabin Medical Center, Petah Tikva, Israel 49100
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Sofi Marom

      Affiliations

    • Anxiety Disorders and Behavior Therapy Unit, Psychiatric Outpatient Clinic, Geha Mental Health Center, Rabin Medical Center, Petah Tikva, Israel 49100
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Jennifer B Levin

      Affiliations

    • Anxiety Disorders and Behavior Therapy Unit, Psychiatric Outpatient Clinic, Geha Mental Health Center, Rabin Medical Center, Petah Tikva, Israel 49100
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Abraham Weizman

      Affiliations

    • Corresponding Author InformationCorresponding author. Geha Psychiatric Hospital, POB 102, Petah Tikva, Israel 49100. Tel.: +972-3-925-8259; Fax: +972-3-924-1041
    • The Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Beilinson Campus, Rabin Medical Center, Petah Tikva, Israel 49100
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Haggai Hermesh

      Affiliations

    • Anxiety Disorders and Behavior Therapy Unit, Psychiatric Outpatient Clinic, Geha Mental Health Center, Rabin Medical Center, Petah Tikva, Israel 49100
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Received 25 February 2001 ,Revised 22 January 2002 ,Accepted 24 January 2002.

References 

  1. Barr CS, Naas A, Freeman M, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 1994;343:327–329
  2. Bazett HC. An analysis of the time relations of electrocardiograms. Heart. 1920;7:353–370
  3. Day CP, McComb JM, Campbell RWF. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br. Heart J. 1990;63:342–344
  4. In:  First MB,  Spitzer RL,  Gibbon M,  Williams JBW editor. Structured Clinical Interview for Axis DSM IV disorders. Patient Edition (SCID-I/P 2.0). New York: Biometrics Research Department, NY State Psychiatric Institute; 1996;
  5. Guler N, Bilge M, Eryonucu B, Kutanis R, Erkoc R. The effect of electroconvulsive therapy on QT dispersion. Acta Cardiol. 1998;53:355–358
  6. Higham PD, Campbell RW. QT dispersion. Br. Heart J. 1994;71:508–510
  7. Ishida S, Nakagawa M, Fujino T, Yonemochi H, Saikawa T, Ito M. Circadian variation of QT interval dispersion: correlation with heart rate variability. J. Electrocardiol. 1997;30:205–210
  8. Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampfer MJ, et al. Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation. 1994;89:1992–1997
  9. Kawachi I, Sparrow D, Vokonas PS, Weiss ST. Decreased heart rate variability in men with phobic anxiety (data from the Normative Aging Study). Am. J. Cardiol. 1995;75:882–885
  10. Kessler RC, McGonale KA, Zhao S, Nelson CB, Hughes M, Eshleman S, et al. Lifetime and 12-month prevalence of psychiatric disorders in the United States; results from the national comorbidity survey. Arch. Gen. Psychiatry. 1994;51:8–19
  11. Lecrubier Y. Comorbidity in social anxiety disorder: Impact on disease burden and management. J. Clin. Psychiatry. 1998;59:33–37
  12. Levin AP, Saoud JB, Strauman T, et al.  Responses of ‘generalized’ and ‘discrete’ social phobices during public speaking. J. Anxiety Disord. 1993;7:207–221
  13. Liebowitz MR. Social phobia. Mod. Probl. Pharmacopsychiatry. 1987;22:141–173
  14. Manttari M, Oikarinen L, Manninen V, Viitasalo M. QT dispersion as a risk factor for sudden cardiac death and fatal myocardial infarction in a coronary risk population. Heart. 1997;78:268–272
  15. Montegomery SA, Asberg MA. A new depression scale designed to be sensitive to change. Br. J. Psychiatry. 1979;134:382–389
  16. Nahshoni E, Aizenberg D, Strasberg B, Dorfman P, Sigler M, Imbar S, et al. QT dispersion in the surface electrocardiogram in elderly patients with major depression. J. Affect. Disord. 2000;60:197–200
  17. Nakagawa M, Takahashi N, Iwao T, Yonemochi H, Ooie T, Hara M, et al. Evaluation of autonomic influences on QT dispersion using the head-up tilt test in healthy subjects. Pacing Clin. Electrophysiol. 1999;22:1158–1163
  18. Papp LA, Gorman JM, Liebowitz MR, Fyer AJ, Cohen B, Klein DF. Epinephrine infusions in patients with social phobia. Am. J. Psychiatry. 1988;145:733–736
  19. Piccirillo G, Viola E, Nocco M, Santagada E, Durante M, Bucca C, et al. Autonomic modulation and QT interval dispersion in hypertensive subjects with anxiety. Hypertension. 1999;34:242–246
  20. Roukema G, Singh JP, Meijs M, Carvalho C, Hart G. Effect of exercise-induced ischemia on QT interval dispersion. Am. Heart J. 1998;135:88–92
  21. Schweitzer P. The values and limitations of the QT interval in clinical practice. Am. Heart J. 1992;124:1121–1124
  22. Statters DJ, Malik M, Ward DE, Camm AJ. QT dispersion: problems of methodology and clinical significance. J. Cardiovasc. Electrophysiol. 1994;5:672–685
  23. Stein MB, Tancer ME, Uhde TW. Heart rate and plasma norepinephrine responsitivity to orthostatic challenge in anxiety disorders. Comparison of patients with panic disorder and social phobia and normal control subjects. Arch. Gen. Psychiatry. 1992;49:311–317
  24. Stein MB, Asmundson GJG, Chartier M. Autonomic responsitivity in generalized social phobia. J. Affect. Disord. 1994;31:211–221
  25. Van de Loo A, Arendts W, Hohloser SH. Variability of QT dispersion measurements in the surface electrocardiogram in patients with acute myocardial infarction and in normal subjects. Am. Cardiol. 1994;74:1113–1118

PII: S0165-0327(02)00052-6

doi: 10.1016/S0165-0327(02)00052-6

Journal of Affective Disorders
Volume 78, Issue 1 , Pages 21-26 , January 2004