Journal of Affective Disorders
Volume 75, Issue 1 , Pages 83-91 , June 2003

The clinical use of gabapentin in bipolar spectrum disorders

  • Mauro Giovanni Carta

      Affiliations

    • Division of Psychiatry, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-070-42760; fax: +39-070-496295
  • ,
  • Maria Carolina Hardoy

      Affiliations

    • Division of Psychiatry, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy
  • ,
  • Maria Julieta Hardoy

      Affiliations

    • Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
  • ,
  • Heinz Grunze

      Affiliations

    • Psychiatrische Klinik der Universitat, LMU, Munich, Germany
  • ,
  • Bernardo Carpiniello

      Affiliations

    • Division of Psychiatry, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy

Received 3 October 2000 ,Accepted 13 December 2001.

References 

  1. Alberti GG, Garini R, Marzolini MN, Belz J, Greco MI, Maresca G. Efficacy and tolerability of gabapentin and valproate in the neuroleptic treatment of acute manic syndromes. Eur. Neuropsychopharmacol. 1999;9(Suppl. 5):S210–211
  2. Altshuler LL, Keck PE, McElroy SL, et al.  Gabapentin in the treatment of refractory bipolar disorders. Bipolar Disord. 1999;1:342–354
  3. Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfeld R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorder. J. Affect. Disord. 2000;59(Suppl. 1):S5–S30
  4. Berezovkaya, A., 1999. Effectiveness of gabapentin in a broad range of psychiatric diagnosis. 152th American Psychiatric Association Annual Meeting, Washington DC, NR731:275.
  5. Bennet J, Goldman WT, Suppes T. Gabapentin for treatment of bipolar and schizoaffective disorders. J. Clin. Psychopharmacol. 1997;17:141–142 letter
  6. Bozikas V, Pehikis P, Phoces C. The use of Gabapentin in the treatment of a patient with bipolar disorder and hepatic dysfunction. Arch. Hellenic Med. 1999;16:602–604
  7. Cabras PL, Hardoy MJ, Hardoy MC, Carta MG. Clinical experience with gabapentin in patients with bipolar and schizoaffective disorder: results of an open label study. J. Clin. Psychiatry. 1999;60:245–248
  8. Carta, M.G., Hardoy, M.J., Hardoy, M.C., Carpiniello, B., Cabras, P.L., 1998a. Gabapentin in mental retardation with bipolar disorders. 151th American Psychiatric Association Annual Meeting, Toronto, NR27:75.
  9. Carta MG, Mameli F, Hardoy MC. Learning disabilities and bipolar spectrum disorders: the use of mood stabilizers. Pychiatric Networks. 1998;1–2:7–20
  10. Carta MG, Hardoy MJ, Hardoy MC, Dessı̀ I, Carpiniello B. Adjunctive gabapentin in patients with intellectual disability and bipolar spectrum disorders. J. Intellect. Disabil. Res. 2001;45:139–145
  11. Crockatt, J., Greiner, M., Clift, L., Pande, A., 1998. Treatment of panic disorder with gabapentin. 38th Annual Meeting, New Clinical Drug Evaluation Unit Program, Boca Raton, FL.
  12. Cora-Locatelli G, Greenberg BD, Martin JD, Murphy DL. Rebound psychiatric and physical symptoms after gabapentin discontinuation. J. Clin. Psychiatry. 1998;59:131
  13. Erfurth A, Kammerer C, Grunze H, et al.  An open label study of gabapentin in the treatment of acute mania. J. Psychiatr. Res. 1998;32:261–264
  14. Ferrier IN. Lamotrigine and gabapentin. Alternative in the treatment of bipolar disorder. Neuropsychobiology. 1998;38:192–197
  15. Frye, M., Ketter, A.T., Osuch, E.A., Kimbrell, T.A., Speer, A.M., Dunn, R.M., Post, M.R., 1998. Gabapentin and lamotrigine monotherapy in mood disorder: an update. American Psychiatric Association Annual Meeting, N77D:150.
  16. Frye M, Ketter TA, Kimbrell TA, et al.  A placebo controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J. Clin. Psychopharmacol. 2000;20:607–614
  17. Garonna F, Meneghin T, Bova F. Efficacia e tollerabilità di gabapentin nel trattamento di pazienti con disturbo bipolare: una analisi retrospettiva. Giorn. Ital. Psicopat. 1998;2:269–272
  18. Ghaemi SN, Katzof JJ, Desai SP, et al.  Gabapentin treatment of mood disorders: a preliminary study. J. Clin. Psychiatry. 1998;59:426–429
  19. Ghaemi SN, Gaughan S. Novel anticonvulsants: a new generation of mood stabilizers. Harv. Rev. Psychiatry. 2000;8:1–7
  20. Grunze H, Erfurth A, Amann B, et al.  Gabapentin in der Behandlung der akuten Manie. Fortschr. Neurol. Psychiatr. 1999;67:1–5
  21. Guille, C., 1999. Gabapentin versus placebo as adjunctive treatment for acute mania and mixed states in Bipolar Disorders. American Psychiatric Association, Annual Meeting, NR10:63.
  22. Hardoy, M.C., Hardoy, M.J., Carta, M.G., Cabras, P.L., 1998. Gabapentin for aggressive behavior. 151th American Psychiatric Association Annual Meeting, Toronto, NR67:85.
  23. Hardoy MJ, Hardoy MC, Carta MG, Cabras PL. Gabapentin in bipolar disorders: does a specific effect on hostility exist?. Psychiatric Networks. 1998;1–2:60–64
  24. Hardoy MC, Hardoy MJ, Carta MG, Cabras PL. Gabapentin as a promising treatment for antipsychotic-induced movement disorders in schizoaffective and bipolar patients. J. Affect. Disord. 1999;54:315–317
  25. Hardoy MJ, Hardoy MC, Carta MG, Cabras PL. Gabapentin in the treatment of bipolar disorders. Bipolar Disord. 1999;1:S1–34
  26. Hauck A, Bhaumick S. Hypomania induced by GBP. Br. J. Psychiatry. 1995;167:549
  27. Hatzimanolis J, Lykoura L, Oulis P, Christodoulou GN. Gabapentin as monotherapy in the treatment of acute mania. Eur. Neuropsychopharmacol. 1999;9(3):257–258
  28. Kelly K. Gabapentin. Antiepileptic mechanism of action. Neuropsychobiology. 1998;38:139–144
  29. Knoll J, Stegman K, Suppes T. Clinical experience using gabapentin adjunctively in patients with a history of mania or hypomania. J. Affect. Disord. 1998;49:229–233
  30. Kumaran, T.S., Shetty, M.K., Lynn, D.J., 1997. Gabapentin for mood instability associated with migraine. 150th American Psychiatric Association Annual Meeting, San Diego, NR130.
  31. Marcotte, D.B., Fogleman, L., Wolfe, N., et al., 1997. Gabapentin: an effective therapy for patients with bipolar affective disorder. 150th American Psychiatric Association Annual Meeting, San Diego, NR:261.
  32. Maurer I, Volz HP, Saurer H. Gabapentin leads to remission of somatoform pain disorder with major depression. Pharmacopsychiatry. 1999;32:255–257
  33. Mauri MC, Laini V, Scalvini M, et al.  Gabapentin, an alternative drug in the prophylaxis of bipolar disorders: preliminary data. Eur. Neuropsychopharmacol. 1998;8(Suppl. 2):S181
  34. McElroy SL, Soutullo CA, Keck PE, Kmetz GF. A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder. Ann. Clin. Psychiatry. 1997;9:99–103
  35. Myrick H, Malcom R, Brady KT. Gabapentin treatment of alcohol withdrawal. Am. J. Psychiatry. 2000;157:151
  36. Olson WL, Gruenthal M, Mueller ME, Olson WH. Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial. Am. J. Med. 1997;102:60–66
  37. Pacileo A, Piro A. Gabapentin in psychiatric patients committed to prison. Eur. Neuropsychopharmacol. 1999;9(Suppl. 5):S355
  38. Pande, A.C., 1999. Combination treatment in bipolar disorders, Bipolar Disord. 1(Suppl.) 1–17.
  39. Pande AC, Davidson J, Jefferson J. Treatment of social phobia with gabapentin: a placebo controlled study. J. Clin. Psychopharmacol. 1999;19:341–348
  40. Pande AC, Crockatt JG, Janney CA, Werth JL, Tsaroucha G. Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group. Bipolar Disord. 2000;2:249–255
  41. Parisi M, Janiri L, Rullo S, et al.  Gabapentin in drug/alcohol dependent inpatients with comorbid psychiatric disorders and subsequent follow-up study. Eur. Neuropsychopharmacol. 1999;9(Suppl. 5):S338
  42. Perugi G, Toni C, Ruffolo G, Sartini S, Simonini E, Akiskal H. Clinical experience using adjunctive gabapentin in treatment-resistant bipolar mixed states. Pharmacopsychiatry. 1999;32:136–141
  43. Pratikakis, N., Koutouvidis, N., Kinakis, S., et al., 1999. A clinical experience with gabapentin in general hospital. XI World Congress of Psychiatry, Hamburg, Vol. II, PO 156:127.
  44. Raja M, Azzoni A. Open naturalistic study of adjunctive gabapentin in the treatment of bipolar spectrum disorder. Eur. Neuropsychopharmacol. 1999;9(Suppl. 5):S249–250
  45. Ryback RS, Brodsky L, Munasifi F. Gabapentin in bipolar disorders. J. Neuropsychiatry Clin. Neurosci. 1997;9:301; letter
  46. Schaffer CB, Schaffer LC. Gabapentin in the treatment of bipolar disorder. Am. J. Psychiatry. 1997;154:291–292 letter
  47. Schaffer CB, Schaffer LC. Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. J. Affect. Disord. 1999;55:237–240
  48. Sheldon L. Gabapentin in psychiatric geriatric patients. Can. J. Psychiatry. 1998;43:422–423 letter
  49. Shetty, M.K., Lynn, D.J., Kumaran, T.S., 1997. Gabapentin for mood instability associated with migraine. Second International Conference on Bipolar Disorder. Western Psychiatric Institute and Clinic (poster # 50), Pittsburgh, PA, USA
  50. Short C, Cooke L. Hypomania induced by gabapentin. Br. J. Psychiatry. 1995;166:679–680
  51. Sokolski KN, Green C, Maris DE, DeMet EM. Gabapentin as an adjunct to standard mood stabilizers in outpatients with mixed bipolar symptomatology. Ann. Clin. Psychiatry. 1999;11:217–222
  52. Stanton SP, Keck PE, McElroy SL. Treatment of acute mania with gabapentin. Am. J. Psychiatry. 1997;154:287; letter
  53. Soutullo CA, Casulo LS, Keck PE. Gabapentin in the treatment of adolescent mania: a case report. J. Child Adolesc. Psychopharmacol. 1998;8:81–85
  54. Taylor CP, Gee NS, Su TZ, et al.  A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 1998;29:233–249
  55. Vieta E, Martnez-Aran A, Nieto E, Colom F, Reinares M, Bernabarre A, et al. Adjunctive Gabapentin treatment of bipolar disorder. Eur. Psychiatry. 2000;15:433–437
  56. Yasmin, S., 2000. Adjunctive gabapentin in treatment of resistant depression. American Psychiatric Association Annual Meeting, Chicago, NR153:97.
  57. Yasmin S, Carpenter LL, Siniscalchi JM, Price LH. Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. J. Affect. Disord. 2000;63:243–247
  58. Young LT, Robb JC, Patelis Siotis I, et al.  Acute treatment of bipolar depression with gabapentin. Biol. Psychiatry. 1997;42:851–853
  59. Young LT, Robb JC, Hasey GM, et al.  Gabapentin as an adjunctive treatment in bipolar disorder. J. Affect. Disord. 1999;55:73–77
  60. Wang, P.W., 2000. Gabapentin in bipolar depression. American Psychiatric Association Annual Meeting, Chicago, NR151:97.
  61. Zaffora, C., 1999. Gabapentin in patients with aggressive symptoms. American Psychiatric Association Annual Meeting, Washington, DC, NR660:255.

PII: S0165-0327(02)00046-0

doi: 10.1016/S0165-0327(02)00046-0

Journal of Affective Disorders
Volume 75, Issue 1 , Pages 83-91 , June 2003