Journal of Affective Disorders
Volume 74, Issue 2 , Pages 185-189 , April 2003

Lifetime burden of mood swings and activation of brain norepinephrine turnover in patients with treatment-refractory depressive illness

  • Anna Ehnvall

      Affiliations

    • Research and Developmental Unit, FoU, Varberg Hospital, SE-432 81 Varberg, Sweden
    • Department of Psychiatry, Institute of Clinical Neuroscience, Göteborg University, Gothenburg, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46-340-481-897; fax: +46-340-833-21
  • ,
  • Magnus Sjögren

      Affiliations

    • Department of Psychiatry, Institute of Clinical Neuroscience, Göteborg University, Gothenburg, Sweden
  • ,
  • Olof C.G. Zachrisson

      Affiliations

    • Department of Psychiatry, Institute of Clinical Neuroscience, Göteborg University, Gothenburg, Sweden
  • ,
  • Hans Ågren

      Affiliations

    • Karolinska Institutet, NEUROTEC, Division of Psychiatry, Huddinge Hospital, SE-141 86 Stockholm, Sweden

Received 1 December 2000 ,Revised 8 December 2001 ,Accepted 19 December 2001.

References 

  1. Ågren H, Mefford IN, Rudorfer MV, Linnoila M, Potter WZ. Interacting neurotransmitter systems. A non-experimental approach to the 5HIAA–HVA correlation in human CSF. J. Psychiatric Res. 1986;20:175–193
  2. Åsberg M, Bertilsson L, Mårtensson B, Scalia-Tomba G-P, Thorén P, Träskman-Bendz L. CSF monoamine metabolites in melancholia. Acta Psychiatr. Scand. 1984;69:201–219
  3. Aston-Jones G, Valentino R, Bockstaele EV, Meyerson A. Locus coeruleus, stress, and PTSD: Neurobiological and clinical parallels. In:  Murburg M editors. Catecholamine Function in Posttraumatic Stress Disorder: Emerging Concepts. Washington, DC: American Psychiatric Press, Inc; 1994;p. 17–62
  4. Banki C, Bissette G, Arato M, O’Connor L, Nemeroff C. CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia. Am. J. Psychiatry. 1987;144:873–877
  5. Blennow K, Wallin A, Gottfries C-G, Lekman A, Karlsson I, Svennerholm L. Significance of decreased lumbar CSF levels of HVA and 5-HIAA in Alzheimer’s disease. Neurobiol. Aging. 1991;13:107–113
  6. Cullinan W, Herman J, Helmreich D, Watson S. A neuroanatomy of stress. In:  Friedman M,  Charney D,  Deutch A editor. Neurobiological and Clinical Consequences of Stress. Philadelphia: Lippincott-Raven Publishers; 1995;p. 3–26
  7. DeBellis M, Baum A, Birmaher B, Keshavan M, Eccard C, Boring A, et al. Developmental traumatology. Part I: Biological stress systems. Biol. Psychiatry. 1999;45:1259–1270
  8. Ehnvall, A., Ågren, H., 2002. Patterns of sensitisation in the course of affective illness: a life-charting study of treatment-refractory depressed patients. J. Affect. Disord., in press.
  9. Geracioti TD, Loosen P, Ekhator N, Schmidt D, Chambliss B, Baker D, et al. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depression Anxiety. 1997;6:89–94
  10. Hsiao JK, Potter WZ, Ågren H, Owen RR, Pickar D. Clinical investigation of monoamine neurotransmitter interactions. Psychopharmacology. 1993;112:76–84
  11. Holsboer F, Liebl R, Hofschuster E. Repeated dexamethasone suppression test during depressive illness: normalizing of test results compared with clinical improvement. J. Affect. Disord. 1982;4:93–101
  12. Koslow S, Maas J, Bowden C, Davis J, Hanin I, Javaid J. CSF and urinary biogenic amines and metabolites in depression and mania. Arch. Gen. Psychiatry. 1983;40:999–1010
  13. McEwen B. Stressful experience, brain, and emotions: developmental, genetic, and hormonal influences. In:  Gazzaniga M editors. The Cognitive Neurosciences. Cambridge, MA: The MIT press; 1995;p. 1117–1135
  14. McEwen B, Stellar E. Stress and the individual: Mechanisms leading to disease. Arch. Int. Med. 1993;153:2093–2101
  15. Nemeroff C. The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Molecular Psychiatry. 1996;1:336–342
  16. Nemeroff C, Widerlöv E, Bissette G. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science. 1984;226:1342–1344
  17. Parnetti L, Gottfries J, Karlsson I. Monoamines and their metabolites in cerebrospinal fluid of patients with senile dementia of Alzheimer type using high performance liquid chromatography and gas chromatography-mass spectometry. Acta Psychiatr. Scand. 1987;75:542–548
  18. Schmider J, Lammers C, Gotthardt V, Dettling M, Holsboer F, Heuser I. Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression and in normal controls: 1. Biol. Psychiatry. 1995;38:797–802
  19. Vestergaard P, Sørensen T, Hoppe E, Rafaelsen O, Yates C, Nicolaou N. Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders. Acta Psychiatr. Scand. 1978;58:88–96
  20. Yehuda R, Giller E, Levengood R, Southwick S, Siever L. Hypothalamic–pituary–adrenal functioning in post-traumatic stress disorder: expanding the concept of the stress response spectrum. In:  Friedman M,  Charney D,  Deutch A editor. Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder. Philadelphia: Lippincott-Raven Publishers; 1995;p. 351–365
  21. Yehuda R, Giller E, Southwick S, Kahana B, Boisenau D, Xiaowan M, et al. Relationship between catecholamine excretion and PTSD symptoms in Vietnam combat Veterans and Holocaust survivors. In:  Murburg M editors. Catacholamine Function in Post-traumatic Stress Disorder. Washington, DC: American Psychiatric Press, Inc; 1994;p. 203–219
  22. Yehuda R, Southwick S, Giller E, Xiaowan M, Mason J. Urinary catecholamine excretion and severity of PTSD symptoms in Vietnam combat veterans. J. Mental Nervous Dis. 1992;180:321–325

PII: S0165-0327(02)00011-3

doi: 10.1016/S0165-0327(02)00011-3

Journal of Affective Disorders
Volume 74, Issue 2 , Pages 185-189 , April 2003