Journal of Affective Disorders
Volume 68, Issue 2 , Pages 183-190 , April 2002

Suicide risk in patients with anxiety disorders: a meta-analysis of the FDA database

  • Arif Khan

      Affiliations

    • Northwest Clinical Research Center, 1900-116th Avenue NE 112, Bellevue, WA 98004, USA
    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-425-453-0404; fax: +1-425-453-1033
    • ,
  • Robyn M Leventhal

      Affiliations

    • Northwest Clinical Research Center, 1900-116th Avenue NE 112, Bellevue, WA 98004, USA
    • ,
  • Shirin Khan

      Affiliations

    • Northwest Clinical Research Center, 1900-116th Avenue NE 112, Bellevue, WA 98004, USA
    • ,
  • Walter A Brown

      Affiliations

    • Department of Psychiatry, Brown University, Providence, RI and Tufts University, Boston, MA, USA

Received 26 December 2000 ,Accepted 21 February 2001.

References 

  1. American Psychiatric Association, 1980. Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition (DSM-III) Washington, DC:APA
  2. American Psychiatric Association, 1987. Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition revised (DSM-IIIR) Washington, DC:APA
  3. Center for Disease Control . CDC WONDERhttp://wonder.cdc.gov/wonder/usr/anonymous/ANONE1A7FF62C2/WDC3BEL0.PCW.00.html.. 2000; Accessed September 19, 2000
  4. Coryell W. Obsessive–compulsive disorder and primary unipolar depression. Comparisons of background, family history, course and mortality. J. Nerv. Ment. Dis. 1981;169(4):220–224
  5. Coryell W, Noyes R, Clancy J. Excess mortality in panic disorder: a comparison with primary unipolar depression. Arch. Gen. Psychiatry. 1982;39:701–703
  6. Cox BJ, Direnfeld BA, Swinson MD, Norton GR. Suicidal ideation and suicide attempts in panic disorder and social phobia. Am. J. Psychiatry. 1994;151:882–887
  7. Friedman S, Jones JC, Chernen L, Barlow DH. Suicidal ideation and suicide attempts among patients with panic disorder: a survey of two outpatient clinics. Am. J. Psychiatry. 1992;149:680–685
  8. Henriksson MM, Isometsa ET, Kuoppasalmi KI, Heikkinen ME, Marttunen MJ, Lonnqvst JK. Panic disorder in completed suicide. J. Clin. Psychiatry. 1996;57:275–280
  9. Hornig CD, McNally RJ. Panic disorder and suicide attempt. A reanalysis of data from the Epidemiologic Catchment area study. British Journal of Psychiatry. 1995;167:76–79
  10. Johnson J, Weissman MM, Kerman GL. Panic disorder, comorbidity and suicide attempts. Arch. Gen. Psychiatry. 1990;47:805–808
  11. Khan A, Warner H, Brown W. Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the food and drug administration database. Arch. Gen. Psychiatry. 2000;57:311–317
  12. Khan, A., Khan, S., Leventhal, R.M., Brown, W.A. Symptom reduction and suicide risk in patients treated with placebo in antipsychotic clinical trials: an analysis of the FDA database. Am J Psychiatry, in press.
  13. Lehmann L, McCormick RA, McCracken L. Suicidal behavior among patients in the VA Health Care System. Psych. Ser. 1995;46(10):1069–1071
  14. Lepine JP, Chignon JM, Teherani M. Suicide attempts in patients with panic disorder. Arch. Gen. Psychiatry. 1993;50:144–149
  15. Noyes R. Suicide and panic disorder: a review. J. Affect. Dis. 1991;22:1–11
  16. Perugi G, Akiskal HS, Ramacciotti S, Nassini S, Toni C, Milanfranchi A, et al. Depressive comorbidity of panic, social phobic, and obsessive-compulsive disorders re-examined: is there a bipolar II connection?. J. Psych. Res. 1999;33:53–61
  17. Schneier FR, Johnson J, Hornig CD, Liebowitz MR, Weissman MM. Comorbidity and morbidity in an epidemiologic sample. Arch. Gen. Psychiatry. 1992;49:282–288
  18. Weissman MM, Klerman GL, Markowitz JS, Ouellette M. Suicidal ideation and suicide attempts in panic disorder and attacks. N. Engl. J. Med. 1989;321:1209–1214
  19. Young LT, Cooke RG, Robb JC, Levitt AJ, Joffe RT. Anxious and non-anxious bipolar disorder. J. Affec. Dis. 1993;29:49–52

PII: S0165-0327(01)00354-8

Journal of Affective Disorders
Volume 68, Issue 2 , Pages 183-190 , April 2002

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