Journal of Affective Disorders
Volume 66, Issue 2 , Pages 199-206 , October 2001

Administration of antidepressants: Single versus split dosing: a meta-analysis

  • Ayşegül Yýldýz

      Affiliations

    • Harvard Medical School, Massachussets General Hospital, Bipolar Clinic and Research Program, Boston, MA, USA
    • Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
    • Corresponding Author InformationCorresponding author. Present address: 170 Sok., Guller Apt. 8/8, PK: 35360, Basin Sitesi, Izmir, Turkey. Tel.: +90-232-244-4724; fax: +90-232-259-9723
    • ,
  • Gary S. Sachs

      Affiliations

    • Harvard Medical School, Massachussets General Hospital, Bipolar Clinic and Research Program, Boston, MA, USA

Received 19 June 2000 ,Accepted 24 August 2000.

References 

  1. Amsterdam JD, Hooper MB, Amchin J. Once versus twice-daily venlafaxine therapy in major depression: a randomized, double blind study. J. Clin. Psychiatry. 1998;59:236–240
  2. Ayd FJ. Once a day neuroleptic and tricyclic antidepressant therapy. Int. Drug Ther. Newsletter. 1972;7:33–40
  3. Ayd FJ. Single daily dose of antidepressants. J. Am. Med. Assoc. 1974;230(2):263–264
  4. Ban TA, Fujimori M, Petrie WM, Ragheb M, Wilson WH. Systematic studies with amoxepine, a new antidepressant. Int. Phramacopsychiatry. 1982;17:18–27
  5. Blier P, De Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol. Sci. 1994;15:220–224
  6. Brooks D, Prothero W, Boura N, Bridges PK, Jarman CMB, Ankier SI. Trazodone; a comparison of single night-time and divided daily dosage regimens. Psychopharmacology. 1984;84:1–4
  7. Cramer JA, Mattson RH, Prevey ML, Sceyer RD, Ouelette VL. How often is medication taken as prescribed?. J. Am. Med. Assoc. 1989;261(22):3273–3277
  8. Davey A. A comparison of two oral dosage regimens of 150 mg trazodone in the treatment of depression in general practice. Psychopharmacology. 1988;95:S25–S30
  9. De Maio D, Sesso M, Minzi A, Cuponeri MA, Mellado C, Bonicalzi M. Evaluation of the clinical efficacy of single daily doses of antidepressants. Prog. Neuro-Psychopharmacol. 1981;4:607–612
  10. Eisen SA, Miller DK, Woodward RS, Spitznagel E. The effect of prescribed daily dose frequency on patient medication compliance. Arch. Intern. Med. 1990;150:1881–1884
  11. Frank P. Comparison of various clomipramine (Anafranil) dosage regimens. J. Int. Med. Res. 1977;5:11–15Suppl. 1
  12. Greenberg RN. Overview of patient compliance with medication dosing: a literature review. Clin. Therapeutics. 1984;6(5):592–599
  13. Heninger GR, Charney DS. Mechanism of action of antidepressant treatments: implications for the etiology and treatment of depressive disorders. In: Psychopharmacology: The Third Generation of Progress. New York: Raven Press; 1987;p. 535–544
  14. Hyman SE, Nestler EJ. Initiation and adaptation: a paradigm for understanding psychotropic drug action. Am. J. Psychiatry. 1996;153:151–162
  15. James RTD, Dean BC. A comparison of a single night-time and divided daily dosage regimen of a chlordiazepoxide–amitriptyline combination. Curr. Med. Res. Opin. 1980;6(8):573–575
  16. Khorana AB. A controlled double blind comparative study of single dose administration of imipramine-pamoate and divided dose of imipramine-hydrochloride in depressive illness. Ind. J. Physiol. Pharmac. 1981;25(4):331–338
  17. Mendels J, Schless AP. A controlled comparison of doxepin h.s. and doxepin q.i.d. J. Clin. Pharmacol. 1975;15:534–539
  18. Mendels J, Schless AP. Antidepressant effects of desipramine administered in two dosage schedules. Dis. Nerv. Syst. 1977;38:249–255
  19. Montgomery S, Mc Auley R, Montgomery DB. Relationship between mianserin plasma levels and antidepressant effect in a double blind trial comparing a single night-time and divided daily dose regimens. J. Clin. Pharmacol. 1978;5:71S–76S
  20. Mungavin JM, Ankier SI. Comparison of two dosage regimens of trazodone in the treatment of depression. Clin. Trails J. 1983;20(4):181–188
  21. Newburn G, Edwards R, Thomas H, Collier J, Fox K, Collins C, et al. A comparison of the efficacy and tolerability of moclobemide given as a single daily dose or in three divided doses per day for the treatment of patients with a major depressive episode. J. Clin. Psychopharmacol. 1995;15(4):10S–15SSuppl. 2
  22. Reimherr FW, Cunningham LA, Basey SR, Johnston JA, Ascher JA. A multicenter evaluation of the efficacy and safety of 150 and 300 mg/day sustained-release bupropion tablets versus placebo in depressed out-patients. Clinical Theurapeutics. 1998;20(3):505–516
  23. Rosin DL, Melia K, Knorr AM, Nestler EJ, Roth RH, Duman RS. Chronic imipramine administration alters the activity and phosphorylation state of tyrosine hydroxylase in dopaminergic regions of rat brain. Neuropsychopharmacol. 1995;12(2):113–121
  24. Schubert DSP, Miller SI. Are divided doses of tricyclic antidepressants necessary?. J. Nerv. Ment. Dis. 1978;166(12):875–877
  25. Schultz JE, Siggins GR, Schocker FW. Effects of prolonged treatment with lithium and tricyclic antidepressants on discharge frequency, norepinephrine response, and beta receptor binding in rat cerebellum: electrophysiological and biochemical comparison. J. Pharmacol. Exp. Ther. 1981;216:28–38
  26. Siddiqui UA, Chakravarti SK, Jesinger DK. The tolerance and antidepressive activity of fluvoxamine as a single dose compared to a twice-daily dose. Curr. Med. Res. Opin. 1985;9:681–690
  27. Snowdon JA. Double blind comparison of three-times daily and single night dosage of amitriptyline with special reference to side effects. Curr. Med. Res. Opin. 1976;4:381–387
  28. Souery D, Mendlewicz J. Compliance and therapeutic issues in resistant depression. Int. Clin. Psychopharmacol. 1998;13:S13–S18Suppl. 2
  29. Stahl SM. Basic psychopharmacology of antidepresssants. Part 1: Antidepressants have seven distinct mechanism of action. J. Clin. Psychiat. 1998;59:5–14Suppl. 4
  30. Sulser F. New perspectives on the molecular pharmacology of affective disorders. Eur. Arch. Psychiatry Neurol. Sci. 1989;238:231–239
  31. Sulser F, Vetulani J, Mobley PL. Mode of action of antidepressant drugs. Biochem. Pharmacol. 1978;27:257–261
  32. Voris JC, Shaurette GN, Sebastian PS, Will-Wallace LA. Nefazodone: single versus twice daily dose. Pharmacotherapy. 1998;18(2):379–380
  33. Watson JM, Tiplady B. Zimelidine: comparison of different dosage regimens in general practice. Acta Psychiatr. Scan. Suppl. 1981;290:464–470
  34. Weise CC, Stein MK, Pereria-Ogan J, Csanalosi I, Rickel K. Amitriptyline once daily versus three times daily in depressed outpatients. Arch. Gen. Psychiatr. 1980;37:555–560
  35. Wheatley D. Trazodone: alternative dose regimens and sleep. Pharmatherapeutica. 1984;3:607–612
  36. Wheatley D. Trazodone in depression. Int. Pharmacopsychiat. 1980;15:240–246
  37. Whitehead A, Whitehead J. A general parametric approach to the meta-analysis of randomized clinical trials. Stat. Med. 1991;10:1665–1677

PII: S0165-0327(00)00307-4

Journal of Affective Disorders
Volume 66, Issue 2 , Pages 199-206 , October 2001

Article Tools

* Image Usage & Resolution