Journal of Affective Disorders
Volume 65, Issue 2 , Pages 139-143 , July 2001

Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder — a negative study

  • Koichiro Fujimaki

      Affiliations

    • Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan
  • ,
  • Shigeru Morinobu

      Affiliations

    • Department of Psychiatry and Neurosciences, Hiroshima University, School of Medicine, Hiroshima, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-82-257-5206; fax: +81-82-257-5209
  • ,
  • Jun Takahashi

      Affiliations

    • Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan
  • ,
  • Shigeto Yamawaki

      Affiliations

    • Department of Psychiatry and Neurosciences, Hiroshima University, School of Medicine, Hiroshima, Japan
  • ,
  • Nobumasa Kato

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  • ,
  • Muneaki Kanno

      Affiliations

    • Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata, Japan
  • ,
  • Naoyuki Okuyama

      Affiliations

    • Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata, Japan
  • ,
  • Shinobu Kawakatsu

      Affiliations

    • Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata, Japan
  • ,
  • Koichi Otani

      Affiliations

    • Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata, Japan
  • ,
  • Ichiro Kusumi

      Affiliations

    • Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
  • ,
  • Tsukasa Koyama

      Affiliations

    • Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan

Received 16 February 2000 ,Accepted 2 June 2000.

References 

  1. Allison JH, Stewart MA. Reduced brain inositol in lithium-treated rats. Nat. New Biol. 1971;233:267–268
  2. Berk M, Bodemer W, van Oudenhove T. The platelet intracellular calcium response to serotonin is augmented in bipolar manic and depressed patients. Hum. Psychopharmacol. 1995;10:189–193
  3. Berridge MJ, Dowens CP, Hanley MR. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 1982;206:587–595
  4. Berridge MJ. Inositol trisphosphate and calcium signaling. Nature. 1993;361:315–325
  5. Berridge MJ. Neuronal calcium signaling. Neuron. 1998;21:13–26
  6. Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH. Calcineurin associated with the inositol 1,4,5-trisphosphate receptor–FKBP12 complex modulates Ca2+ flux. Cell. 1995;83:463–472
  7. Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, et al. FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine–proline (1400–1401) and anchors calcineurin to this FK506-like domain. J. Biochem. 1997;272:27582–27588
  8. Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996;16:89–101
  9. Dubovsky SL, Lee C, Christiano J, Murphy J. Elevated platelet intracellular calcium concentration in bipolar disorder. Biol. Psychiatry. 1991;29:441–450
  10. Furuichi T, Yoshikawa S, Miyawaki A, Wada K, Maeda N, Mikoshiba K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-bonding protein P400. Nature. 1989;342:32–38
  11. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985;260:3440–3450
  12. Ghosh A, Greenberg ME. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science. 1995;268:239–247
  13. Hallcher LM, Sherman WR. The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J. Biol. Chem. 1981;255:10896–10901
  14. Kendall DA, Nahorski SR. Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex. J. Pharmacol. Exp. Ther. 1987;241:1023–1027
  15. Kusumi I, Koyama T, Yamashita I. Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients. Biol. Psychiatry. 1991;30:310–312
  16. Kusumi I, Koyama T, Yamashita I. Effect of mood stabilizing agents on agonist-induced calcium mobilization in human platelets. J. Psychiatry Neurosci. 1994;19:222–225
  17. Kusumi I, Koyama T. Serotonin-2A receptor function in affective disorder. In:  Ozawa H, et al. editor. Signal Transduction in Affective Disorders. Tokyo: Springer; 1998;p. 21–34
  18. Li W, Llopis J, Whitney M, Zlokarnile G, Tsien RY. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature. 1998;392:936–941
  19. Manji HK, Potter WZ, Lenox RH. Signal transduction pathways: molecular targets for lithium actions. Arch. Gen. Psychiatry. 1995;52:531–543
  20. Mayford M, Bach ME, Huang YT, Wang L, Hawkins RD, Kandel ER. Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996;274:1678–1683
  21. Okamoto Y, Kagaya A, Shinno H, Motohashi N, Yamawaki S. Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci. 1995;56:327–332
  22. Yamada M, Makino Y, Clark RA, Pearson DW, Mattei MG, Guenet JL, et al. Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization. Biochem. J. 1994;302:781–790
  23. Yamawaki S, Kagaya A, Okamoto Y, Shimizu M, Nishida A, Uchitomi Y. Enhanced calcium response to serotonin in platelets from patients with affective disorders. J. Psychiatry Neurosci. 1996;21:321–324

PII: S0165-0327(00)00273-1

Journal of Affective Disorders
Volume 65, Issue 2 , Pages 139-143 , July 2001