Journal of Affective Disorders
Volume 36, Issue 1 , Pages 37-42, 24 December 1995

Circadian variation of plasma cobalamin, transcobalamin-bound cobalamin and unsaturated binding capacity of transcobalamin and haptocorrin in healthy elderly

  • Karin Sparring Björkstén

      Affiliations

    • Corresponding Author InformationCorresponding author. Fax: (46) (13) 22 38 94.
    • Department of Psychiatry, Faculty of Health Sciences, University Hospital, S-58I 85 Linköping, Sweden
    • ,
  • Lars-Håkan Thorell

      Affiliations

    • Department of Psychiatry, Faculty of Health Sciences, University Hospital, S-58I 85 Linköping, Sweden
    • ,
  • Ebba Nexø

      Affiliations

    • Department of Clinical Biochemistry, University Hospital, Aarhus, Nørrebrogade 44, DK-8000 Aarhus, Denmark

Received 17 January 1995; received in revised form 19 June 1995; accepted 19 June 1995.

Abstract 

Blood samples were drawn every second hour during a 24-h period from healthy elderly subjects. Plasma levels of cobalamin, albumin, transcobalamin-bound cobalamin and unsaturated binding capacity of transcobalamin and haptocorrin were determined. During night, all components decreased in parallel with plasma albumin. The nocturnal decreases were therefore ascribed to plasma volume changes due to bed-rest. Reports on the recently proposed role of cobalamin for the biological clock were reviewed, but the proposed role could not be explained by this study.

Keywords:  Cobalamin, Haptocorrin, Transcobalamin, Plasma, Circadian rhythm, Ageing

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PII: 0165-0327(95)00051-8

Journal of Affective Disorders
Volume 36, Issue 1 , Pages 37-42, 24 December 1995

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